Department of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, Guizhou, China.
J Med Virol. 2024 Jul;96(7):e29772. doi: 10.1002/jmv.29772.
The distinct composition and immune response characteristics of bats' innate and adaptive immune systems, which enable them to serve as host of numerous serious zoonotic viruses without falling ill, differ substantially from those of other mammals, it have garnered significant attention. In this article, we offer a systematic review of the names, attributes, and functions of innate and adaptive immune cells & molecules across different bat species. This includes descriptions of the differences shown by research between 71 bat species in 10 families, as well as comparisons between bats and other mammals. Studies of the immune cells & molecules of different bat species are necessary to understand the unique antiviral immunity of bats. By providing comprehensive information on these unique immune responses, it is hoped that new insights will be provided for the study of co-evolutionary dynamics between viruses and the bat immune system, as well as human antiviral immunity.
蝙蝠先天和适应性免疫系统的独特组成和免疫反应特征，使它们能够作为许多严重人畜共患病病毒的宿主而不生病，这与其他哺乳动物有很大的不同，引起了人们的极大关注。在本文中，我们对不同蝙蝠物种的先天和适应性免疫细胞和分子的名称、属性和功能进行了系统综述。这包括对 10 个科的 71 种蝙蝠物种之间的研究差异的描述，以及蝙蝠与其他哺乳动物之间的比较。研究不同蝙蝠物种的免疫细胞和分子对于了解蝙蝠独特的抗病毒免疫至关重要。通过提供有关这些独特免疫反应的全面信息，希望为病毒与蝙蝠免疫系统以及人类抗病毒免疫之间的共同进化动态的研究提供新的见解。
