Zhang Qian, Li Yufeng, Yang Xiaoliang, Fang Zeguo, Li Dong
New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base, School of Materials and Chemical Engineering, Hubei University of Technology, Wuhan 430068, China.
Org Lett. 2024 Jul 12;26(27):5620-5624. doi: 10.1021/acs.orglett.4c01431. Epub 2024 Jul 1.
Palladium/norbornene cooperatively catalyzed Catellani-type reactions were normally limited to aryl iodides as substrates. The employment of aryl bromides has remained challenging. Herein a Pd/NBE cooperatively catalyzed Catellani-type reaction of 2-bromoaryl ketone is described. The 2-bromoaryl ketone was employed as both substrates and arylation reagents with a Heck acceptor. A decarbonylation process of the ketones also occurred in the reaction, finishing the modular -Heck/,-diarylation in one pot. It provided the functionalized -triphenyl derivatives with three new C-C bonds in moderate to excellent yields which exhibited good regioselectivities and functional group tolerance.
钯/降冰片烯协同催化的卡泰拉尼型反应通常仅限于以芳基碘化物作为底物。使用芳基溴化物仍然具有挑战性。本文描述了钯/降冰片烯协同催化的2-溴芳基酮的卡泰拉尼型反应。2-溴芳基酮既用作底物，又用作与Heck受体的芳基化试剂。反应中还发生了酮的脱羰过程，一锅完成了模块化的Heck/双芳基化反应。它以中等至优异的产率提供了具有三个新碳-碳键的官能化三苯基衍生物，这些衍生物表现出良好的区域选择性和官能团耐受性。
