School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran (Dr Tajalli and Mr Vafaee); and Neonatal Health Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran (Drs Safi, Navidi Moghaddam, and Fallahi).
Adv Neonatal Care. 2024 Aug 1;24(4):349-353. doi: 10.1097/ANC.0000000000001174. Epub 2024 Jun 27.
Acquired human cytomegalovirus (CMV) is a noteworthy disease in infants. This case study will highlight the influence of early diagnosis of CMV retinitis (CMVR) on avoid visual impairment.
We describe a preterm female infant with a birth weight of 2060 gr that was admitted for tracheostomy placement due to hypoxic-ischemic encephalopathy. There were no signs of CMV infection or sepsis in laboratory results upon admission such as serology (IgG, IgM antibodies), Toxoplasma gondii , Rubella virus, Herpes simplex virus, CMVR and urine polymerase chain reaction (PCR).
Incidentally, upon screening for retinopathy of prematurity, diffuse occlusive vasculitis was detected in the retinal image on the 112th day of life.
Intravenous and intraocular ganciclovir were administered for 4 weeks.
In the follow-up visit 6 weeks after discharge from the hospital, visual impairment was detected on both sides.
This is a report of a case of acquired CMVR, a silent finding, as an uncommon complication in preterm neonates during the hospital stay. This diagnosis should be taken into consideration in preterm infants, since early diagnosis and treatment are crucial to avoid visual impairment.
获得性人巨细胞病毒（CMV）是婴儿期的一种重要疾病。本病例研究将强调早期诊断 CMV 视网膜炎（CMVR）对避免视力损害的影响。
我们描述了一名患有低氧缺血性脑病的早产儿女婴，其出生体重为 2060 克，因需要进行气管切开术而入院。入院时实验室检查结果（如血清学 IgG、IgM 抗体、弓形虫、风疹病毒、单纯疱疹病毒、CMVR 和尿液聚合酶链反应（PCR））均未显示 CMV 感染或败血症的迹象。
在早产儿视网膜病变筛查过程中，在生命第 112 天的视网膜图像上发现弥漫性闭塞性血管炎。
静脉和眼内给予更昔洛韦治疗 4 周。
出院后 6 周的随访中，发现双侧视力受损。
这是一例获得性 CMVR 的病例报告，这是一种沉默的发现，是早产儿在住院期间一种罕见的并发症。应考虑在早产儿中进行这种诊断，因为早期诊断和治疗对于避免视力损害至关重要。
