Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Department of Clinical Laboratory and Immunology, Military Medical Academy, Sofia, Bulgaria.
J Interferon Cytokine Res. 2024 Aug;44(8):379-385. doi: 10.1089/jir.2024.0083. Epub 2024 Jul 1.
COVID-19, caused by the SARS-CoV-2 virus, has caused a global health crisis, necessitating a deeper understanding of its pathophysiology. In this study, we explored the immune and hematological dynamics in COVID-19 patients to gain insights into disease severity and prognosis. Our findings revealed distinct cytokine profiles in moderate and severe cases. was significantly upregulated in peripheral blood mononuclear cells from moderate cases, suggesting a potential role in initiating an effective immune response. Conversely, severe cases exhibited downregulation of key pro-inflammatory cytokines () alongside an upregulation of the immunosuppressive , indicative of a dysregulated immune environment. Serum analysis showed elevated IL6 and IL10 levels in both moderate and severe cases, emphasizing their potential as markers for disease severity. Notably, no significant differences in serum cytokines were found between recovery and lethal cases. In lethal cases of COVID-19, elevated D-dimer, urea, and creatinine correlated with IL6 and IL10. This study contributes valuable information to the ongoing efforts to understand and manage the dysregulated immune responses underlying COVID-19 pathology.
由 SARS-CoV-2 病毒引起的 COVID-19 引发了全球卫生危机，需要更深入地了解其病理生理学。在这项研究中，我们探讨了 COVID-19 患者的免疫和血液动力学变化，以深入了解疾病的严重程度和预后。我们的研究结果揭示了中度和重度病例中不同的细胞因子谱。在中度病例的外周血单核细胞中显著上调，提示其在启动有效免疫反应方面可能发挥作用。相反，严重病例中关键促炎细胞因子下调，同时免疫抑制细胞因子上调，表明免疫环境失调。血清分析显示，中度和重度病例中 IL6 和 IL10 水平升高，强调其作为疾病严重程度标志物的潜力。值得注意的是，在 COVID-19 恢复和致死病例之间，血清细胞因子无显著差异。在 COVID-19 的致死病例中，升高的 D-二聚体、尿素和肌酐与 IL6 和 IL10 相关。这项研究为了解和管理 COVID-19 病理生理学中失调的免疫反应提供了有价值的信息。
