Cancer Metastasis Alert and Prevention Center, College of Chemistry, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China.
College of Chemistry, Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), Fuzhou University, Fuzhou, Fujian 350116, China.
ACS Nano. 2024 Jul 16;18(28):18230-18245. doi: 10.1021/acsnano.4c00650. Epub 2024 Jul 1.
Therapy-induced modulation of the tumor microenvironment (TME) to overcome the immunosuppressive TME is considered to be an opportunity for cancer treatment. However, monitoring of TME modulation during the therapeutic process to accurately determine immune responses and adjust treatment plans in a timely manner remains to be challenging. Herein, we report a carrier-free nanotheranostic system (CANPs) assembled by two boron dipyrromethene (BODIPY) dyes, a sonophotosensitizer C-BDP, and a nitric oxide (NO) probe amino-BODIPY (A-BDP). CANPs can exert combined sonophototherapeutic effects of C-BDP under ultrasound and light irradiation and simultaneously induce inflammatory TME, as well as emit bright fluorescence via A-BDP by monitoring tumor-associated macrophages (TAMs) repolarization through the released NO in vitro and in vivo. Of note, transforming growth factor-β (TGF-β) could be the key cytokine involved in the sonophototherapy-induced TME reprogramming. By virtue of high physiological stability, good biocompatibility, and effective tumor targetability, CANPs could be a potential nanotheranostic system for the simultaneous induction and detection of TME reprogramming triggered by sonophototherapy.
治疗诱导的肿瘤微环境（TME）调节以克服免疫抑制性 TME 被认为是癌症治疗的一个机会。然而，在治疗过程中监测 TME 调节以准确确定免疫反应并及时调整治疗计划仍然具有挑战性。在此，我们报告了一种由两种硼二吡咯甲川（BODIPY）染料、声敏剂 C-BDP 和一氧化氮（NO）探针氨基酸-BODIPY（A-BDP）组装的无载体纳米治疗系统（CANPs）。CANPs 可以在超声和光照射下发挥 C-BDP 的联合声光治疗作用，同时通过体外和体内释放的 NO 诱导炎症性 TME，并通过 A-BDP 发出明亮的荧光，从而监测肿瘤相关巨噬细胞（TAMs）的重极化。值得注意的是，转化生长因子-β（TGF-β）可能是声光疗诱导的 TME 重编程中涉及的关键细胞因子。由于具有高生理稳定性、良好的生物相容性和有效的肿瘤靶向性，CANPs 可以成为一种潜在的纳米治疗系统，用于同时诱导和检测声光疗触发的 TME 重编程。
