Hoogland P V, Vanderkrans A, Koole F D, Groenewegen H J
Neurosci Lett. 1985 May 23;56(3):323-8. doi: 10.1016/0304-3940(85)90263-0.
The centrifugal projection to the eye has been studied in rats with anterograde and retrograde tracing techniques. As a retrograde tracer Nuclear Yellow (NY) was used. Following NY injections into the vitreous body of the eye, labeled neurons were exclusively found bilaterally in nucleus oculomotorius. The course and termination site of the retinopetal fibers were studied with the anterograde tracer Phaseolus vulgaris-leucoagglutinin (PHA-L). Iontophoretic injections of PHA-L in nucleus oculomotorius resulted in labeling of retinopetal fibers which reach the eye via the optic tract and optic nerve. Preterminal arborizations were found in the inner nuclear layer of the retina. In addition, labeled fibers have been observed which seem to terminate within the optic tract and optic nerve. It is suggested that the projection from the nucleus oculomotorius to the retina constitutes a link in the multisynaptic efferent pathway from the visual cortex to the eye, by which the visual cortex can influence the functioning of the retina.
利用顺行和逆行示踪技术，对大鼠眼球的离心投射进行了研究。使用核黄（NY）作为逆行示踪剂。将NY注入眼球玻璃体后，仅在双侧动眼神经核中发现了标记神经元。用顺行示踪剂菜豆白细胞凝集素（PHA-L）研究了视网膜向心性纤维的走行和终末部位。在动眼神经核中进行PHA-L的离子电渗注射，导致通过视束和视神经到达眼球的视网膜向心性纤维被标记。在视网膜内核层发现了终末前分支。此外，还观察到标记纤维似乎终止于视束和视神经内。提示动眼神经核向视网膜的投射构成了从视觉皮层到眼球的多突触传出通路中的一个环节，通过该通路视觉皮层可以影响视网膜的功能。
