Sledge G W, Ramzy I, Dressler L G, Dorr F A, Adams D J, McGuire W L
Obstet Gynecol. 1985 Sep;66(3):423-7.
The presence of an estrogen-regulated protein of Mr 24,000 (24K) was studied in 43 patients diagnosed as having endometrial adenocarcinoma. using an anti-24K monoclonal antibody, a modified immunoperoxidase system (avidinbiotin complex) was used to detect the presence of 24K in formalin-fixed, paraffin-embedded tissue samples. The positivity for 24K was correlated with low tumor histologic grade, few mitotic figures, few nucleoli, and a low degree of nuclear pleomorphism. These data suggest that 24K may be a potential marker of tumor differentiation.
对43例诊断为子宫内膜腺癌的患者，研究了分子量为24,000（24K）的雌激素调节蛋白的存在情况。使用抗24K单克隆抗体，采用改良的免疫过氧化物酶系统（抗生物素蛋白-生物素复合物）检测福尔马林固定、石蜡包埋组织样本中24K的存在情况。24K的阳性与低肿瘤组织学分级、少量有丝分裂象、少量核仁以及低度核异型性相关。这些数据表明24K可能是肿瘤分化的一个潜在标志物。
