特立帕肽剂量和频率差异对股骨近端骨结构的影响。-基于 DXA 的 3D 建模（3D-SHAPER 软件）分析-TRIPLE-BONE 研究（特立帕肽制剂对骨矿物质密度增加和骨结构的影响）。

Effects of differences in dose and frequency of teriparatide on bone structure in Proximal Femur. - Analysis by DXA-based 3D-modeling (3D-SHAPER Software) -TRIPLE-BONE study (The effects of TeRIParatide preparation on bone mineraL density increase and BONE structure).

机构信息

Osteoporosis Center, Sapporo Maruyama Orthopaedic Hospital, 1-3, N-7, W-27, Chuo-ku, Sapporo, 060-0007, Japan.

Sapporo Kotoni Orthopaedic, Sapporo, Hokkaido, Japan.

出版信息

Arch Osteoporos. 2024 Jul 2;19(1):55. doi: 10.1007/s11657-024-01415-1.

DOI:10.1007/s11657-024-01415-1

PMID:38954145

Abstract

UNLABELLED

Trends toward more favorable improvement of the cortical bone parameters by once-weekly (56.5 μg once a week) and twice-weekly teriparatide (28.2 μg twice a week), and that of the trabecular bone parameters by once-daily (1/D) teriparatide (20 μg/day once a day) were shown.

PURPOSE

To examine the effects of differences in the amount of teriparatide (TPTD) per administration and its dosing frequency on the bone structure in the proximal femur by dual-energy X-ray absorptiometry (DXA)-based 3D-modeling (3D-SHAPER software).

METHODS

This was a multicenter retrospective study. Patients aged 50 years or older with primary osteoporosis who continuously received once-/twice-weekly (1・2/W, n = 60) or 1/D TPTD (n = 14) administration for at least one year were included in the study. Measurement regions included the femoral neck (FN), trochanter (TR), femoral shaft (FS), and total proximal hip (TH). Concurrently, the bone mineral density (BMD) and Trabecular Bone Score (TBS) were measured.

RESULTS

The cross-sectional area, cross-sectional moment of inertia, and section modulus in the FS were significantly improved in the 1・2/W TPTD group, as compared to the 1/D TPTD group. However, significant improvement of the cortical thickness and buckling ratio in the FN was observed in the 1/D TPTD group, as compared to the 1・2/W TPTD group. Trabecular BMD values in the FS and TH were significantly increased in the 1/D TPTD group, as compared to the 1・2/W TPTD group, while the cortical BMD values in the TR, FS, and TH were significantly increased in the 1・2/W TPTD group, as compared to the 1/D TPTD group.

CONCLUSION

Trends toward more favorable improvement of the cortical bone by 1・2/W TPTD and that of the trabecular bones by 1/D TPTD were observed.

摘要

未加标签

研究表明，每周一次（56.5μg 每周一次）和每周两次（28.2μg 每周两次）给予特立帕肽以及每日一次（1/D）给予特立帕肽（20μg/天，每日一次）均可改善皮质骨参数，每日一次给予特立帕肽还可改善松质骨参数。

目的

通过双能 X 射线吸收法（DXA）三维建模（3D-SHAPER 软件）研究单次给药特立帕肽剂量和给药频率对股骨近端骨结构的影响。

方法

这是一项多中心回顾性研究。纳入年龄≥50 岁、患有原发性骨质疏松症且持续接受每周一次/两次（1・2/W，n=60）或每日一次（1/D）特立帕肽治疗至少 1 年的患者。测量部位包括股骨颈（FN）、转子间（TR）、股骨干（FS）和整个近端髋部（TH）。同时，测量骨密度（BMD）和骨小梁评分（TBS）。

结果

与 1/D 特立帕肽组相比，1・2/W 特立帕肽组 FS 的横截面积、横截面惯性矩和截面模量显著改善。然而，1/D 特立帕肽组 FN 的皮质厚度和翘曲比显著改善，而 1・2/W 特立帕肽组无显著改善。1/D 特立帕肽组 FS 和 TH 的松质骨 BMD 值显著增加，而 1・2/W 特立帕肽组 TR、FS 和 TH 的皮质骨 BMD 值显著增加。