Brance María Lorena, Saraví Fernando Daniel, Henríquez Muriel M, Larroudé María Silvia, Jacobo Jorge E, Araujo Sebastian Abalo, Longobardi Vanesa, Zanchetta María Bélen, Ulla María Rosa, Martos Florencia, Salerni Helena, Oliveri Beatriz, Bonanno Marina Soledad, Meneses Naraline Luna, Baclini Pilar Diaz, Ramírez Stieben Luis A, Di Gregorio Silvana, Brun Lucas R
Reumatología y Enfermedades Óseas, Rosario, Santa Fe, Argentina.
Bone Biology Laboratory, School of Medicine, Rosario National University, Rosario, Santa Fe, Argentina.
J Bone Metab. 2024 Nov;31(4):279-289. doi: 10.11005/jbm.24.765. Epub 2024 Nov 30.
There are age- and sex-related increases in the prevalence of osteoporosis. Bone densitometry based on dual energy X-ray absorptiometry (DXA) is the gold standard for the assessment of bone mineral density (BMD). Three-dimensional (3D) analysis of the proximal femur (3D-DXA) allows discrimination between cortical and trabecular compartments, and it has shown a good correlation with computed tomography. We aimed to assess age- and sex-related volumetric density differences in trabecular and cortical bone using 3D-DXA and determine the reference intervals for integral volumetric (v)BMD within the Argentine population.
Healthy female and male adult subjects (N=1,354) from Argentina were included. Hip BMD was measured using DXA, and 3D analysis was performed using 3D-Shaper software. The integral vBMD, cortical surface BMD, and trabecular vBMD (trab vBMD) were measured.
The study population included 73.9% women (N=1,001) and 26.13% men (N=353). We found a significant decrease in integral vBMD between 20 and 90 years in both sexes (women, -23.1%; men, -16.6%). Bone loss indicated in the integral vBMD results was mainly due to a decrease in trabecular bone in both sexes (women, -33.4%; men, -27.7%). The age-related loss of cortical bone density was less and was limited to the female population, without no age-related differences in men. Moreover, 3D-DXA allowed us to propose reference intervals for integral vBMD.
We found age- and sex-related bone loss between 20 and 90 years in an Argentine cohort via integral vBMD measurements using 3D-DXA, mainly due to decreases in trabecular bone in both sexes. The age-related loss of cortical bone density was less and was limited to the female population.
骨质疏松症的患病率存在与年龄和性别相关的增长。基于双能X线吸收法（DXA）的骨密度测定是评估骨矿物质密度（BMD）的金标准。股骨近端的三维（3D）分析（3D-DXA）能够区分皮质骨和小梁骨区域，并且已显示出与计算机断层扫描有良好的相关性。我们旨在使用3D-DXA评估小梁骨和皮质骨中与年龄和性别相关的体积密度差异，并确定阿根廷人群中整体体积（v）BMD的参考区间。
纳入来自阿根廷的健康成年女性和男性受试者（N = 1354）。使用DXA测量髋部BMD，并使用3D-Shaper软件进行三维分析。测量整体vBMD、皮质表面BMD和小梁vBMD（trab vBMD）。
研究人群包括73.9%的女性（N = 1001）和26.13%的男性（N = 353）。我们发现20至90岁之间两性的整体vBMD均显著下降（女性为-23.1%；男性为-16.6%）。整体vBMD结果显示的骨量流失主要是由于两性小梁骨减少（女性为-33.4%；男性为-27.7%）。与年龄相关的皮质骨密度流失较少，且仅限于女性人群，男性没有与年龄相关的差异。此外，3D-DXA使我们能够提出整体vBMD的参考区间。
通过使用3D-DXA测量整体vBMD，我们在阿根廷队列中发现了20至90岁之间与年龄和性别相关的骨质流失，主要原因是两性小梁骨减少。与年龄相关的皮质骨密度流失较少，且仅限于女性人群。
