Faculty of Mechanical Engineering, Department of BioMechanical Engineering, Bio-Inspired Technology (BITE) Group, Delft University of Technology, Delft, The Netherlands.
Department of Biomedical Engineering & Physics, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
PLoS One. 2024 Jul 2;19(7):e0306411. doi: 10.1371/journal.pone.0306411. eCollection 2024.
Transperineal laser ablation is a minimally invasive thermo-ablative treatment for prostate cancer that requires the insertion of a needle for accurate optical fiber positioning. Needle insertion in soft tissues may cause tissue motion and deformation, resulting in tissue damage and needle positioning errors. In this study, we present a wasp-inspired self-propelled needle that uses pneumatic actuation to move forward with zero external push force, thus avoiding large tissue motion and deformation. The needle consists of six parallel 0.25-mm diameter Nitinol rods driven by a pneumatic actuation system. The pneumatic actuation system consists of Magnetic Resonance (MR) safe 3D-printed parts and off-the-shelf plastic screws. A self-propelled motion is achieved by advancing the needle segments one by one, followed by retracting them simultaneously. The advancing needle segment has to overcome a cutting and friction force, while the stationary needle segments experience a friction force in the opposite direction. The needle self-propels through the tissue when the friction force of the five stationary needle segments overcomes the sum of the friction and cutting forces of the advancing needle segment. We evaluated the prototype's performance in 10-wt% gelatin phantoms and ex vivo porcine liver tissue inside a preclinical Magnetic Resonance Imaging (MRI) scanner in terms of the slip ratio of the needle with respect to the phantom or liver tissue. Our results demonstrated that the needle was able to self-propel through the phantom and liver tissue with slip ratios of 0.912-0.955 and 0.88, respectively. The prototype is a promising step toward the development of self-propelled needles for MRI-guided transperineal laser ablation as a method to treat prostate cancer.
经会阴激光消融术是一种微创热消融治疗前列腺癌的方法,需要插入一根针来实现光纤的精确定位。在软组织中插入针可能会导致组织运动和变形,从而造成组织损伤和针定位错误。在这项研究中,我们提出了一种受黄蜂启发的自动推进针,它使用气动致动器实现零外部推力的前进运动,从而避免了大的组织运动和变形。该针由六个平行的 0.25 毫米直径的镍钛诺棒组成,由气动致动系统驱动。气动致动系统由磁共振(MR)安全的 3D 打印部件和现成的塑料螺丝组成。通过逐个推进针段并同时缩回它们来实现自动推进运动。推进的针段必须克服切割和摩擦力,而静止的针段则会受到相反方向的摩擦力。当五个静止的针段的摩擦力克服推进的针段的摩擦力和切割力之和时,针就会在组织中自动推进。我们在临床前磁共振成像(MRI)扫描仪内的 10wt%明胶体模和离体猪肝组织中评估了原型的性能,以评估针相对于体模或肝组织的滑动比。我们的结果表明,该针能够在体模和肝组织中自动推进,滑动比分别为 0.912-0.955 和 0.88。该原型是朝着开发用于 MRI 引导经会阴激光消融的自动推进针以治疗前列腺癌的方法迈出的有前途的一步。