[教育程度增加患过敏性鼻炎和（或）湿疹的风险：一项基于欧洲患者全基因组关联研究的孟德尔随机化研究]
[Educational attainment increases the risk of developing allergic rhinitis and (or) eczema: a Mendelian randomization study based on genome-wide association studies in European patients].
作者信息
Zheng R, Liu Z F, Chen Z G, Huang X K, Feng P Y, Qiu H J, Lu Y X, Chen J J, Zhang Y N, Zhang J R, Yang Q T
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China Department of Allergy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China Key Laboratory of Airway Inflammatory Disease Research and Innovative Technology Translation, Guangzhou, Guangzhou 510630, China.
Department of Clinical Data Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
出版信息
Zhonghua Yu Fang Yi Xue Za Zhi. 2024 Jun 6;58(6):791-798. doi: 10.3760/cma.j.cn112150-20230830-00138.
To determine the causal relationship between educational attainment and the risk of allergic rhinitis and (or) eczema using Mendelian randomization (MR) analyses. This study was a secondary data analysis based on the summary data of genome-wide association studies (GWAS), which involved 293 723 participants (educational attainment) from the Social Science Genetics Association Consortium and 462 013 participants [allergic rhinitis and (or) eczema] from the UK Biobank. Genetic variants that were closely related to educational attainment were identified as instrumental variables. Two-sample MR analyses, including inverse-variance weighted (IVW), MR-Egger regression, weighted median method and weighted model-based estimation, were performed to investigate the causal relationship between educational attainment and the risk of allergic rhinitis and (or) eczema, in which the odds ratio () values were used as indicators. A total of 70 single-nucleotide polymorphisms (SNPs) were chosen as instrumental variables. The MR-Egger regression results suggested that the genetic pleiotropy was unlikely to bias our results (=0.107). In the univariable MR analyses, IVW regression showed that the risk of allergic rhinitis and (or) eczema was =1.044 (95%: 1.020-1.069, 0.001) and =1.170 (95%: 1.074-1.256, 0.001), respectively, for the increase in the duration of education by one year or one standard deviation () (3.71 years). In the reverse MR analysis, IVW regression showed little evidence that allergic rhinitis and (or) eczema affected educational attainment (=1.020, 95%: 0.927-1.023, 0.683). The results of the weighted median method and weighted mode-based estimation were consistent with the results of IVW. This study suggests that there is a positive causal relationship between educational attainment and the risk of allergic rhinitis and (or) eczema, which means that educational attainment can increase the occurrence of allergic rhinitis and (or) eczema.
使用孟德尔随机化（MR）分析来确定教育程度与过敏性鼻炎和（或）湿疹风险之间的因果关系。本研究是基于全基因组关联研究（GWAS）汇总数据的二次数据分析，涉及社会科学遗传协会联盟的293723名参与者（教育程度）和英国生物银行的462013名参与者[过敏性鼻炎和（或）湿疹]。与教育程度密切相关的基因变异被确定为工具变量。进行了双样本MR分析，包括逆方差加权（IVW）、MR-Egger回归、加权中位数法和基于加权模型的估计，以研究教育程度与过敏性鼻炎和（或）湿疹风险之间的因果关系，其中比值比（OR）值用作指标。总共选择了70个单核苷酸多态性（SNP）作为工具变量。MR-Egger回归结果表明，基因多效性不太可能使我们的结果产生偏差（P=0.107）。在单变量MR分析中，IVW回归显示，教育年限每增加一年或一个标准差（SD）（3.71年），过敏性鼻炎和（或）湿疹的风险分别为OR=1.044（95%CI：1.020-1.069，P<0.001）和OR=1.170（95%CI：1.074-1.256，P<0.001）。在反向MR分析中，IVW回归几乎没有显示过敏性鼻炎和（或）湿疹影响教育程度的证据（OR=1.020，95%CI：0.927-1.023，P=0.683）。加权中位数法和基于加权模型估计的结果与IVW的结果一致。本研究表明，教育程度与过敏性鼻炎和（或）湿疹风险之间存在正因果关系，这意味着教育程度会增加过敏性鼻炎和（或）湿疹的发生。
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