癌胚抗原在宫颈内膜腺癌和子宫内膜腺癌中的免疫组织化学定位。

Immunohistochemical localization of carcinoembryonic antigen in adenocarcinoma of the endocervix and the endometrium.

作者信息

Toki T, Oikawa N, Tase T, Wada Y, Yajima A, Suzuki M

出版信息

Tohoku J Exp Med. 1985 May;146(1):27-32. doi: 10.1620/tjem.146.27.

DOI:10.1620/tjem.146.27

Abstract

Immunoperoxidase localization of carcinoembryonic antigen (CEA) was performed on tissue sections of adenocarcinoma of endocervical and endometrial origin to clarify the criteria for their differentiation. Twenty-two (96%) of 23 endocervical and 32 (70%) of 46 endometrial adenocarcinomas revealed positive CEA immunostain. The extent of staining did not seem to correlate with the degree of differentiation in either kind of cancer. Among the positive cases, CEA staining was located over whole cytoplasm in 18 (80%) of 22 positive endocervical adenocarcinomas and on apical surface in 24 (75%) of 32 positive endometrial adenocarcinomas. The pattern of CEA distribution in endocervical adenocarcinoma of endometrioid type was not similar to that observed for primary endometrial adenocarcinoma.

摘要

为明确宫颈内膜腺癌和子宫内膜腺癌的鉴别标准，对其组织切片进行癌胚抗原（CEA）免疫过氧化物酶定位。23例宫颈内膜腺癌中有22例（96%）、46例子宫内膜腺癌中有32例（70%）显示CEA免疫染色阳性。两种癌症的染色程度似乎均与分化程度无关。在阳性病例中，22例阳性宫颈内膜腺癌中有18例（80%）的CEA染色位于整个细胞质，32例阳性子宫内膜腺癌中有24例（75%）的CEA染色位于顶端表面。子宫内膜样型宫颈内膜腺癌的CEA分布模式与原发性子宫内膜腺癌不同。