在常规组织学组织标本中，通过癌胚抗原免疫过氧化物酶染色鉴别宫颈内膜腺癌和子宫内膜腺癌。

Distinction between endocervical and endometrial adenocarcinoma with immunoperoxidase staining of carcinoembryonic antigen in routine histological tissue specimens.

作者信息

Wahlström T, Lindgren J, Korhonen M, Seppälä M

出版信息

Lancet. 1979 Dec 1;2(8153):1159-60. doi: 10.1016/s0140-6736(79)92386-9.

Abstract

The differential diagnosis of endocervical and endometrial adenocarcinomas can be improved by the demonstration of carcinoembryonic antigen (CEA) in tissue by means of immunoperoxidase staining. Tissue from 131 (80%) of 163 patients with endocervical adenocarcinoma but only 11 (8%) of 137 patients with endometrial adenocarcinoma was CEA-positive. The commonest exceptions were endocervical mesonephroid adenocarcinomas (which were CEA-negative) and endometrial adenosquamous carcinomas (which were CEA-positive). After exclusion of these on simple morphological criteria, 86 of 107 endocervical adenocarcinomas (80%) were CEA-positive, and all 122 endometrial adenocarcinomas were CEA-negative. The remarkable difference in the expression of CEA between endocervical and endometrial adenocarcinomas suggests a novel application of immunohistochemistry in routine clinical practice.

摘要

通过免疫过氧化物酶染色法在组织中显示癌胚抗原（CEA），可改善宫颈内膜腺癌和子宫内膜腺癌的鉴别诊断。163例宫颈内膜腺癌患者中的131例（80%）组织CEA呈阳性，而137例子宫内膜腺癌患者中只有11例（8%）组织CEA呈阳性。最常见的例外情况是宫颈中肾样腺癌（CEA阴性）和子宫内膜腺鳞癌（CEA阳性）。根据简单的形态学标准排除这些病例后，107例宫颈内膜腺癌中的86例（80%）CEA呈阳性，而所有122例子宫内膜腺癌CEA均为阴性。宫颈内膜腺癌和子宫内膜腺癌之间CEA表达的显著差异提示免疫组化在常规临床实践中的新应用。