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猫和狗肾脏中肾小管和集合管的种特异性组织学特征。

Species-specific histological characterizations of renal tubules and collecting ducts in the kidneys of cats and dogs.

机构信息

Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

Laboratory of Laboratory Animal Science and Medicine, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

出版信息

PLoS One. 2024 Jul 3;19(7):e0306479. doi: 10.1371/journal.pone.0306479. eCollection 2024.

DOI:10.1371/journal.pone.0306479
PMID:38959226
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11221681/
Abstract

The histomorphological features of normal kidneys in cats and dogs have been revealed despite the high susceptibility of cats to tubulointerstitial damage. Herein, the histological characteristics of the two species were compared. Cytoplasmic lipid droplets (LDs) were abundant in the proximal convoluted tubules (PCTs) of cats aged 23-27 months but scarce in dogs aged 24-27 months. LDs were rarely observed in the distal tubules (DTs) and collecting ducts (CDs) of either species, as visualized by the expression of Tamm-Horsfall protein 1, calbindin-D28K, and aquaporin 2. The occupational area ratio of proximal tubules (PTs) in the renal cortex was higher, but that of DTs or CDs was significantly lower in adult cats than in dogs. Single PT epithelial cells were larger, but PCT, DT, and CD lumens were significantly narrower in adult cats than in dogs. Unlike adults, young cats at 6 months exhibited significantly abundant cytoplasmic LDs in proximal straight tubules, indicating lipid metabolism-related development. Histochemistry of the 21 lectins also revealed variations in glycosylation across different renal tubules and CDs in both species. Sodium-glucose cotransporter 2 was expressed only in PTs, excluding the proximal straight tubules with few LDs in adult cats or the PCTs of young cats and adult dogs. These findings are crucial for understanding species-specific characteristics of renal histomorphology and pathogenesis.

摘要

尽管猫对肾小管间质损伤高度敏感，但仍揭示了猫和狗正常肾脏的组织形态学特征。在此，比较了这两个物种的组织学特征。23-27 月龄猫的近端曲管（PCT）中富含细胞质脂滴（LDs），而 24-27 月龄狗的 PCT 中则很少。通过 Tamm-Horsfall 蛋白 1、钙结合蛋白 D28K 和水通道蛋白 2 的表达，在两种物种的远曲小管（DT）和集合管（CD）中很少观察到 LDs。与狗相比，成年猫的肾皮质中近端小管（PT）的职业面积比更高，但 DT 或 CD 的职业面积比显著更低。与狗相比，成年猫的单个 PT 上皮细胞更大，但 PCT、DT 和 CD 管腔明显更窄。与成年人不同，6 月龄的幼猫在近端直小管中表现出明显丰富的细胞质 LDs，表明与脂质代谢相关的发育。21 种凝集素的组织化学染色也揭示了两种物种不同肾单位和 CD 中糖基化的变化。钠-葡萄糖共转运蛋白 2 仅在 PT 中表达，不包括成年猫中 LD 较少的近端直小管或幼猫和成年狗的 PCT。这些发现对于理解肾脏组织形态学和发病机制的种特异性特征至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bdb/11221681/d739e5ffa9e3/pone.0306479.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bdb/11221681/d739e5ffa9e3/pone.0306479.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bdb/11221681/306e6be3aded/pone.0306479.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bdb/11221681/e3052fbf293e/pone.0306479.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bdb/11221681/4e1945c74045/pone.0306479.g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bdb/11221681/d739e5ffa9e3/pone.0306479.g007.jpg

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