Lin Jiaxin, Li Yingru, Feng Xiaochuang, Zhang Yu, Wang Jiahao, Liao Weilin, Li Hongming, Yi Xiaojiang, Gan Wenchang, Yuan Zhilong, Liu Fuheng, Shi Lishuo, Zeng Bing, Diao Dechang
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.
Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China.
Cancer. 2025 Jan 1;131(1):e35452. doi: 10.1002/cncr.35452. Epub 2024 Jul 3.
The surgical treatment of retroperitoneal sarcoma (RPS) is highly challenging because of its complex anatomy. In this study, the authors compared the surgical outcomes of patients with RPS who underwent surgical resection guided by three-dimensional (3D) printing technology versus traditional imaging.
This retrospective study included 251 patients who underwent RPS resection guided by 3D-printing technology or traditional imaging from January 2019 to December 2022. The main outcome measures were operative time, intraoperative blood loss, postoperative complications, and hospital stay.
In total, 251 patients were enrolled in the study: 46 received 3D-printed navigation, and 205 underwent traditional surgical methods. Propensity score matching yielded 44 patients in the 3D group and 82 patients in the control group. The patients' demographics and tumor characteristics were comparable in the matched cohorts. The 3D group had significantly shorter operative time (median, 186.5 minutes [interquartile range (IQR), 130.0-251.3 minutes] vs. 210.0 minutes [IQR, 150.8-277.3 minutes]; p = .04), less intraoperative blood loss (median, 300.0 mL [IQR, 100.0-575.0 mL] vs. 375.0 mL [IQR, 200.0-925.0 mL]; p = .02), shorter postoperative hospital stays (median, 11.0 days [IQR, 9.0-13.0 days] vs. 14.0 days [IQR, 10.8-18.3 days]; p = .02), and lower incidence rate of overall postoperative complications than the control group (18.1% vs. 36.6%; p = .03). There were no differences with regard to the intraoperative blood transfusion rate, the R0/R1 resection rate, 30-day mortality, or overall survival.
Patients in the 3D group had favorable surgical outcomes compared with those in the control group. These results suggest that 3D-printing technology might overcome challenges in RPS surgical treatment.
The surgical treatment of retroperitoneal sarcoma (RPS) is highly challenging because of its complex anatomy. The purpose of this study was to investigate whether three-dimensional (3D) printing technology offers advantages over traditional two-dimensional imaging (such as computed tomography and magnetic resonance imaging) for guiding the surgical treatment of RPS. In a group of patients who had RPS, surgery guided by 3D-printing technology was associated with better surgical outcomes, including shorter operative time, decreased blood loss, shorter hospital stays, and fewer postoperative complications. These findings suggested that 3D-printing technology could help surgeons overcome challenges in the surgical treatment of RPS. 3D-printing technology has important prospects in the surgical treatment of RPS.
由于腹膜后肉瘤（RPS）解剖结构复杂，其手术治疗极具挑战性。在本研究中，作者比较了接受三维（3D）打印技术引导下手术切除的RPS患者与接受传统成像引导下手术切除的患者的手术结果。
这项回顾性研究纳入了2019年1月至2022年12月期间接受3D打印技术或传统成像引导下RPS切除的251例患者。主要观察指标为手术时间、术中出血量、术后并发症及住院时间。
本研究共纳入251例患者：46例接受3D打印导航，205例采用传统手术方法。倾向评分匹配后，3D组有44例患者，对照组有82例患者。匹配队列中患者的人口统计学特征和肿瘤特征具有可比性。3D组的手术时间显著更短（中位数为186.5分钟[四分位间距（IQR）为130.0 - 251.3分钟]，而对照组为210.0分钟[IQR为150.8 - 277.3分钟]；p = 0.04），术中出血量更少（中位数为300.0 mL[IQR为100.0 - 575.0 mL]，而对照组为375.0 mL[IQR为200.0 - 925.0 mL]；p = 0.02），术后住院时间更短（中位数为11.0天[IQR为9.0 - 13.0天]，而对照组为14.0天[IQR为10.8 - 18.3天]；p = 0.02），且总体术后并发症发生率低于对照组（18.1%对36.6%；p = 0.03）。术中输血率、R0/R1切除率、30天死亡率或总生存率方面无差异。
与对照组相比，3D组患者的手术结果更佳。这些结果表明，3D打印技术可能克服RPS手术治疗中的挑战。
由于腹膜后肉瘤（RPS）解剖结构复杂，其手术治疗极具挑战性。本研究的目的是调查三维（3D）打印技术在指导RPS手术治疗方面是否优于传统二维成像（如计算机断层扫描和磁共振成像）。在一组患有RPS的患者中，3D打印技术引导下的手术与更好的手术结果相关，包括更短的手术时间、减少的出血量、更短的住院时间和更少的术后并发症。这些发现表明，3D打印技术可以帮助外科医生克服RPS手术治疗中的挑战。3D打印技术在RPS手术治疗中具有重要前景。
