Angelkort B, Spürk P, Habbaba A, Mähder M
Angiology. 1985 May;36(5):285-92. doi: 10.1177/000331978503600504.
Recent investigations suggest an interdependence between blood fluidity and walking performance in patients with peripheral arterial occlusive disease (PAOD). Therefore, various blood fluidity variables (erythrocyte aggregation, erythrocyte flexibility, plasma viscosity, plasma proteins) were studied in groups of healthy subjects and claudicants with severe PAOD (exhausted perfusion reserve) receiving intravenous treatment with Trental (600 mg Pentoxifylline b.i.d., 21 days). Erythrocyte flexibility (expressed by filterability through micropore filters), red cell aggregation and plasma viscosity deteriorate with progression of disease especially in Stage IIb and III Fontaine classification, with walking distance below 150 m. Trental treatment resulted in patients with advanced POAD stages in improvement of red cell filterability, red cell aggregation, decrease of plasma viscosity, increase in absolute walking distance and relief from rest pain, suggesting that such patients are accessible to conservative treatment with hemorheologically active agents.
近期研究表明，外周动脉闭塞性疾病（PAOD）患者的血液流动性与行走能力之间存在相互依存关系。因此，我们对健康受试者组以及患有严重PAOD（灌注储备耗尽）且正在接受曲克芦丁静脉治疗（己酮可可碱600毫克，每日两次，共21天）的间歇性跛行患者，研究了各种血液流动性变量（红细胞聚集、红细胞柔韧性、血浆粘度、血浆蛋白）。随着疾病进展，尤其是在Fontaine分类的IIb期和III期，当行走距离低于150米时，红细胞柔韧性（通过微孔滤器的过滤性表示）、红细胞聚集和血浆粘度会恶化。曲克芦丁治疗使晚期PAOD患者的红细胞过滤性得到改善、红细胞聚集减少、血浆粘度降低、绝对行走距离增加且静息痛缓解，这表明此类患者可接受血液流变学活性剂的保守治疗。
