Ciuffetti G, Mercuri M, Ott C, Lombardini R, Paltriccia R, Lupattelli G, Santambrogio L, Mannarino E
2nd Department of Internal Medicine, University of Perugia, Italy.
Eur J Clin Pharmacol. 1991;41(6):511-5. doi: 10.1007/BF00314976.
The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow positive-pressure system), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen pressure (PtcO2) during treadmill exercise to stress leg circulation was also measured. Leucocyte-derived free radicals were generated during peripheral ischaemia. Pentoxifylline inhibited their generation, blocked the release of reactive oxygen metabolites, and reduced impairment of the filterability rate of unfractionated leucocytes. The improvements were accompanied by significant shortening of the half-time of recovery of transcutaneous oxygen pressure, indicating that ischaemic damage had been contained.
在一项双盲安慰剂对照研究中，已确定静脉输注1克己酮可可碱作为自由基生成抑制剂的效果。在两组各10名II期外周血管疾病患者中，于治疗前后测量了白细胞衍生的自由基生成（通过超氧化物歧化酶抑制的高铁细胞色素还原）、活性氧代谢产物的释放（作为血浆氧化活性）、未分级白细胞和红细胞的过滤率（使用恒流正压系统）、血浆粘度和血浆纤维蛋白原浓度。还测量了跑步机运动期间用于评估腿部循环应激的经皮氧分压（PtcO2）。外周缺血期间会产生白细胞衍生的自由基。己酮可可碱抑制了它们的生成，阻止了活性氧代谢产物的释放，并减少了未分级白细胞过滤率的损害。这些改善伴随着经皮氧分压恢复半衰期的显著缩短，表明缺血损伤得到了控制。
