1,4,5,6-四氢-2-甲基-4-嘧啶羧酸（THMP）——来自嗜盐单胞菌属的用于药物应用的新型通用应激蛋白数据
1, 4, 5, 6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid (THMP) - A novel universal stress protein data from Halomonas species for pharmaceutical applications.
作者信息
Rekadwad Bhagwan Narayan
机构信息
Microbe AI Lab, Division of Microbiology and Biotechnology, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangaluru, Karnataka, 575018, India.
出版信息
Data Brief. 2024 Mar 1;54:110272. doi: 10.1016/j.dib.2024.110272. eCollection 2024 Jun.
Genomes of Halomonas species have been studied using the BV-BRC Bioinformatics tool for the presence of CDS, non-CDS, AMR genes, VF genes, transporters, drug targets, GC content, and GC skew from outside to the center of the circular view, followed by phylogenetic analysis of unique 1, 4, 5, 6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid (THMP) gene clusters for relatedness within the genus Halomonas. Protein structure and chemical structure of 1, 4, 5, 6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid (THMP) encoded by the UspA gene in Halomonas strains and amino acid sequence of the novel UspA gene have been predicted by computational method.
已使用BV-BRC生物信息学工具研究了嗜盐单胞菌属物种的基因组，以确定其环状视图从外到中心的编码序列（CDS）、非编码序列（non-CDS）、抗菌药物抗性（AMR）基因、毒力因子（VF）基因、转运蛋白、药物靶点、鸟嘌呤-胞嘧啶（GC）含量和GC偏移，随后对嗜盐单胞菌属内独特的1,4,5,6-四氢-2-甲基-4-嘧啶羧酸（THMP）基因簇进行系统发育分析，以确定其亲缘关系。通过计算方法预测了嗜盐单胞菌菌株中UspA基因编码的1,4,5,6-四氢-2-甲基-4-嘧啶羧酸（THMP）的蛋白质结构和化学结构，以及新型UspA基因的氨基酸序列。
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