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非甾体类抗炎药使用继发的产后症状性消化性溃疡病新发病例

New Onset of Symptomatic Peptic Ulcer Disease Postpartum Secondary to Nonsteroidal Anti-Inflammatory Drug Use.

作者信息

Tallmadge Maggie, MacBeth Margaret, Palatnik Anna

机构信息

Department of Obstetrics and Gynecology Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

出版信息

Case Rep Obstet Gynecol. 2024 Jun 11;2024:6422824. doi: 10.1155/2024/6422824. eCollection 2024.

DOI:10.1155/2024/6422824
PMID:38962291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11221993/
Abstract

The use of nonsteroidal anti-inflammatory drug (NSAID) medications is a risk factor for peptic ulcer disease (PUD). PUD in the postpartum period is rare, despite the common use of NSAIDs. A G1P0 presented 6 days postcesarean section with fatigue, lightheadedness, melenic stools, and a hemoglobin of 5.4 g/dL after using NSAIDs and acetaminophen for postoperative pain control. An esophagogastroduodenoscopy (EGD) was performed for a suspected upper gastrointestinal bleed and found one gastric and one duodenal ulcer. Though typically used for a short course in the postpartum period, NSAIDs remain a predisposing risk factor for PUD postpartum, and patients and providers must be aware of this risk.

摘要

使用非甾体抗炎药(NSAID)是消化性溃疡病(PUD)的一个危险因素。尽管NSAIDs使用普遍,但产后发生PUD的情况很少见。一名初产妇在剖宫产术后6天出现疲劳、头晕、黑便,在使用NSAIDs和对乙酰氨基酚控制术后疼痛后血红蛋白为5.4 g/dL。因怀疑上消化道出血进行了食管胃十二指肠镜检查(EGD),发现一个胃溃疡和一个十二指肠溃疡。虽然NSAIDs在产后通常短期使用,但它仍然是产后PUD的一个诱发危险因素,患者和医疗人员必须意识到这种风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4914/11221993/44647d2e13d0/CRIOG2024-6422824.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4914/11221993/950db49b9a79/CRIOG2024-6422824.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4914/11221993/44647d2e13d0/CRIOG2024-6422824.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4914/11221993/950db49b9a79/CRIOG2024-6422824.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4914/11221993/44647d2e13d0/CRIOG2024-6422824.002.jpg

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本文引用的文献

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Acute upper gastrointestinal bleed in the puerperium following weight reduction surgery.产后减肥手术后的急性上消化道出血。
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How do NSAIDs cause ulcer disease?非甾体抗炎药是如何引发溃疡病的?
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