Nishimiya K, Auer G U, Erhardt K, Wiman L G, Kato H, Hayata Y
Anal Quant Cytol Histol. 1985 Jun;7(2):153-8.
The nuclear DNA content in morphologically identified tumor cells was analyzed in 4-micron histologic sections from 58 patients with lung carcinoma who survived for at least five years. Thirty-three of the carcinomas were invasive squamous bronchial carcinomas and 25 were pulmonary adenocarcinomas. In all squamous carcinomas, the majority of tumor cells were found to exhibit DNA values exceeding the normal tetraploid and/or diploid region. In contrast, some of the pulmonary adenocarcinomas were found to be composed of a majority of tumor cells with DNA values in the normal diploid region. The results indicate that invasive squamous bronchial carcinomas, in general, are tumors with aneuploid DNA patterns indicative of a high malignant potential and that malignancy grading based on DNA measurements does not add any significant prognostic information to that obtained by morphologic diagnosis.
对58例存活至少5年的肺癌患者的4微米组织学切片中形态学鉴定的肿瘤细胞的核DNA含量进行了分析。其中33例为浸润性支气管鳞癌，25例为肺腺癌。在所有鳞癌中，发现大多数肿瘤细胞的DNA值超过正常四倍体和/或二倍体区域。相比之下，发现一些肺腺癌由大多数DNA值处于正常二倍体区域的肿瘤细胞组成。结果表明，浸润性支气管鳞癌通常是具有非整倍体DNA模式的肿瘤，提示其具有高恶性潜能，并且基于DNA测量的恶性分级并未为形态学诊断所获得的预后信息增添任何显著内容。
