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结肠腺瘤性息肉中细胞核倍性与组织学的相关性

Correlation of nuclear ploidy with histology in adenomatous polyps of colon.

作者信息

Jarvis L R, Graff P S, Whitehead R

出版信息

J Clin Pathol. 1987 Jan;40(1):26-33. doi: 10.1136/jcp.40.1.26.

DOI:10.1136/jcp.40.1.26
PMID:3818972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1140824/
Abstract

Histological sections of adenomatous polyps of the colon showing carcinoma were studied by video image analysis. Nuclear DNA content and morphology were measured in regions identified as either dysplasia, carcinoma confined to the mucosa, or carcinoma invading the muscularis mucosa. Where carcinoma was present, areas of dysplasia in the same polyp were found to have similar distributions of nuclear DNA content and size, supporting the notion that adenomatous polyps becomes cancer. The method can be used to detect those regions in sections of adenomatous polyps with the most severe nuclear abnormality.

摘要

通过视频图像分析研究了显示有癌的结肠腺瘤性息肉的组织学切片。在被确定为发育异常、局限于黏膜的癌或侵犯黏膜肌层的癌的区域测量核DNA含量和形态。在存在癌的情况下，发现同一息肉中的发育异常区域具有相似的核DNA含量和大小分布，支持腺瘤性息肉会发展为癌的观点。该方法可用于检测腺瘤性息肉切片中核异常最严重的那些区域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f61d/1140824/e3393d74c564/jclinpath00321-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f61d/1140824/3d246a13e78b/jclinpath00321-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f61d/1140824/dd8b86f6cb9f/jclinpath00321-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f61d/1140824/e3393d74c564/jclinpath00321-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f61d/1140824/3d246a13e78b/jclinpath00321-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f61d/1140824/dd8b86f6cb9f/jclinpath00321-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f61d/1140824/e3393d74c564/jclinpath00321-0037-b.jpg

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本文引用的文献

1
Pathology of colorectal adenomas: a colonoscopic survey.结直肠腺瘤的病理学：一项结肠镜检查调查。
J Clin Pathol. 1982 Aug;35(8):830-41. doi: 10.1136/jcp.35.8.830.
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The evolution of colorectal carcinoma.结直肠癌的演变
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Adenomas: preneoplastic events, growth and development in man and experimental systems.腺瘤：人类及实验系统中的肿瘤前病变、生长与发展
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Ploidy studies in adenomatous polyps of the colon.结肠腺瘤性息肉的倍性研究。
J Clin Pathol. 1985 Nov;38(11):1261-4. doi: 10.1136/jcp.38.11.1261.
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DNA ploidy measurements in tissue sections.
Anal Quant Cytol Histol. 1985 Jun;7(2):90-6.
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Nuclear DNA in histologic sections from squamous-cell carcinoma and adenocarcinoma of the lung.来自肺鳞状细胞癌和腺癌组织切片中的核DNA。
Anal Quant Cytol Histol. 1985 Jun;7(2):153-8.
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A microcomputer system for video image analysis and diagnostic microdensitometry.
Anal Quant Cytol Histol. 1986 Sep;8(3):201-9.