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二甲双胍可预防椎间盘退变的发生和进展：新的见解和潜在机制（综述）。

Metformin prevents the onset and progression of intervertebral disc degeneration: New insights and potential mechanisms (Review).

机构信息

Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.

Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.

出版信息

Int J Mol Med. 2024 Aug;54(2). doi: 10.3892/ijmm.2024.5395. Epub 2024 Jul 4.

DOI:10.3892/ijmm.2024.5395
PMID:38963023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11232665/
Abstract

Metformin has been the go‑to medical treatment for addressing type 2 diabetes mellitus (T2DM) as a frontline oral antidiabetic. Obesity, cancer and bone deterioration are linked to T2DM, which is considered a metabolic illness. Numerous diseases associated with T2DM, such as tumours, cardiovascular disease and bone deterioration, may be treated with metformin. Intervertebral disc degeneration (IVDD) is distinguished by degeneration of the spinal disc, accompanied by the gradual depletion of proteoglycans and water in the nucleus pulposus (NP) of the IVD, resulting in lower back pain. The therapeutic effect of metformin on IVDD has also attracted much attention. By stimulating AMP‑activated kinase, metformin could enhance autophagy and suppress cell senescence, apoptosis and inflammation, thus effectively delaying IVDD. The present review aimed to systematically explain the development of IVDD and mechanism of metformin in the treatment and prevention of IVDD to provide a reference for the clinical application of metformin as adjuvant therapy in the treatment of IVDD.

摘要

二甲双胍一直是治疗 2 型糖尿病（T2DM）的一线口服抗糖尿病药物。肥胖症、癌症和骨恶化与 T2DM 有关，T2DM 被认为是一种代谢疾病。二甲双胍可用于治疗许多与 T2DM 相关的疾病，如肿瘤、心血管疾病和骨恶化。椎间盘退行性变（IVDD）的特征是椎间盘退变，伴随着椎间盘核（NP）中蛋白聚糖和水分的逐渐耗尽，导致腰痛。二甲双胍对 IVDD 的治疗作用也引起了广泛关注。通过刺激 AMP 激活的蛋白激酶，二甲双胍可以增强自噬并抑制细胞衰老、凋亡和炎症，从而有效延缓 IVDD。本综述旨在系统阐述 IVDD 的发生发展以及二甲双胍在治疗和预防 IVDD 中的作用机制，为二甲双胍作为辅助治疗药物治疗 IVDD 的临床应用提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/70f51d6acc89/ijmm-54-02-05395-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/7f59c0bc4b54/ijmm-54-02-05395-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/af455ab18b2b/ijmm-54-02-05395-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/14da721a7354/ijmm-54-02-05395-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/70f51d6acc89/ijmm-54-02-05395-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/7f59c0bc4b54/ijmm-54-02-05395-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/af455ab18b2b/ijmm-54-02-05395-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/14da721a7354/ijmm-54-02-05395-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c66/11232665/70f51d6acc89/ijmm-54-02-05395-g03.jpg

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[7]
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引用本文的文献

[1]
Shared diagnostic genes and potential mechanisms between intervertebral disc degeneration and diabetes mellitus revealed by integrated transcriptomic analysis and machine learning.

Front Endocrinol (Lausanne). 2025-7-18

本文引用的文献

[1]
Sirtuins in intervertebral disc degeneration: current understanding.

Mol Med. 2024-3-29

[2]
SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway.

Eur J Med Res. 2023-9-25

[3]
Association of insomnia with incident chronic cognitive impairment in older adults with type 2 diabetes mellitus: A prospective study of the Hong Kong Diabetes Register.

J Diabetes Complications. 2023-10

[4]
Focus on the impact of social factors and lifestyle on the disease burden of low back pain: findings from the global burden of disease study 2019.

BMC Musculoskelet Disord. 2023-8-26

[5]
Evaluation of PEN2-ATP6AP1 axis as an antiparasitic target for metformin based on phylogeny analysis and molecular docking.

Mol Biochem Parasitol. 2023-9

[6]
Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases.

Aging Dis. 2024-4-1

[7]
Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes.

Drug Des Devel Ther. 2023

[8]
Aging, cell senescence, the pathogenesis and targeted therapies of intervertebral disc degeneration.

Front Pharmacol. 2023-5-5

[9]
Erratum: Abridged for Primary Care Providers. Clin Diabetes 2023;41:4-31.

Clin Diabetes. 2023

[10]
Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis.

Biomed Pharmacother. 2023-5

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