Kamp Benedikt, Radke Karl Ludger, Knet Marek, Strunk Rosanna, Gallinnis Patrik J, Nagel Armin M, Filler Timm J, Antoch Gerald, Abrar Daniel B, Frenken Miriam, Wittsack Hans-Jörg, Müller-Lutz Anja
Department of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
J Magn Reson Imaging. 2025 Mar;61(3):1503-1512. doi: 10.1002/jmri.29521. Epub 2024 Jul 4.
Lower back pain affects 75%-85% of people at some point in their lives. The detection of biochemical changes with sodium (Na) MRI has potential to enable an earlier and more accurate diagnosis.
To measure Na relaxation times and apparent tissue sodium concentration (aTSC) in ex-vivo intervertebral discs (IVDs), and to investigate the relationship between aTSC and histological Thompson grade.
Ex-vivo.
Thirty IVDs from the lumbar spines of 11 human body donors (4 female, 7 male, mean age 86 ± 8 years).
FIELD STRENGTH/SEQUENCE: 3 T; density-adapted 3D radial sequence (DA-3D-RAD).
IVD Na longitudinal (T), short and long transverse (T* and T*) relaxation times and the proportion of the short transverse relaxation (p) were calculated for one IVD per spine sample (11 IVDs). Furthermore, aTSCs were calculated for all IVDs. The degradation of the IVDs was assessed via histological Thompson grading.
A Kendall Tau correlation (τ) test was performed between the aTSCs and the Thompson grades. The significance level was set to P < 0.05.
Mean Na relaxation parameters of a subset of 11 IVDs were T = 9.8 ± 1.3 msec, T* = 0.7 ± 0.1 msec, T* = 7.3 ± 1.1 msec, and p = 32.7 ± 4.0%. A total of 30 IVDs were examined, of which 3 had Thompson grade 1, 4 had grade 2, 5 had grade 3, 5 had grade 4, and 13 had grade 5. The aTSC decreased with increasing degradation, being 274.6 ± 18.9 mM for Thompson grade 1 and 190.5 ± 29.5 mM for Thompson grade 5. The correlation between whole IVD aTSC and Thompson grade was significant and strongly negative (τ = -0.56).
This study showed a significant correlation between aTSC and degenerative IVD changes. Consequently, aTSC has potential to be useful as an indicator of degenerative spinal changes.
2 TECHNICAL EFFICACY: Stage 1.
下背痛在75%-85%的人一生中的某个阶段会出现。利用钠（Na）磁共振成像检测生化变化有可能实现更早、更准确的诊断。
测量离体椎间盘（IVD）的钠弛豫时间和表观组织钠浓度（aTSC），并研究aTSC与组织学汤普森分级之间的关系。
离体研究。
来自11名人体捐赠者腰椎的30个IVD（4名女性，7名男性，平均年龄86±8岁）。
场强/序列：3T；密度适应三维径向序列（DA-3D-RAD）。
计算每个脊柱样本中的一个IVD（共11个IVD）的IVD钠纵向（T）、短和长横向（T和T）弛豫时间以及短横向弛豫比例（p）。此外，计算所有IVD的aTSC。通过组织学汤普森分级评估IVD的退变情况。
对aTSC和汤普森分级进行肯德尔tau相关（τ）检验。显著性水平设定为P<0.05。
11个IVD子集的平均钠弛豫参数为T = 9.8±1.3毫秒，T* = 0.7±0.1毫秒，T* = 7.3±1.1毫秒，p = 32.7±4.0%。共检查了30个IVD，其中3个为汤普森1级，4个为2级，5个为3级，5个为4级，13个为5级。aTSC随退变加重而降低，汤普森1级时为274.6±18.9毫摩尔，汤普森5级时为190.5±29.5毫摩尔。整个IVD的aTSC与汤普森分级之间的相关性显著且呈强负相关（τ = -0.56）。
本研究表明aTSC与退变的IVD变化之间存在显著相关性。因此，aTSC有可能作为脊柱退变变化的一个指标。
2 技术效能：1级
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