Scheipers Anna K, Grimm Johannes A, Losch Jana, Orzada Stephan, Fiedler Thomas M, Nagel Armin M, Schmitter Sebastian, Ladd Mark E, Platt Tanja
Medical Physics in Radiology, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.
Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany.
Magn Reson Med. 2025 Nov;94(5):1930-1945. doi: 10.1002/mrm.30605. Epub 2025 Jun 22.
To combine large field-of-view abdominal and quantitative sodium ( ) MRI in the same position at 7 T to enable the quantification of the tissue sodium concentration via MRI and the anatomical assignment in images without repositioning in several tissues and organs at once.
A custom-built birdcage coil and reference vial setup together with a 32-channel pTx array were employed at 7 T to allow dual-nuclei MRI in the same position for a field-of-view (FOV) of . relaxation effects in the reference vials and phantom were corrected, maps were measured, and maps were simulated to correct the acquired data in post-processing. These corrections were evaluated in a phantom and then applied in vivo in three healthy volunteers.
In the phantom, it was demonstrated that proton and quantitative sodium MR images share the same large FOV. Phantom measurements showed an improved sodium concentration accuracy after the performed corrections. Large FOV and quantitative in vivo MRI was demonstrated in three healthy volunteers.
This work shows the feasibility of combined and quantitative imaging at 7 T in a large FOV both under free breathing in , laying the ground work for an accurate evaluation of the tissue sodium concentration in several organs at once.
在7T场强下，在同一位置结合大视野腹部磁共振成像（MRI）和定量钠（）MRI，以便通过MRI对组织钠浓度进行定量分析，并在不重新定位的情况下对多个组织和器官的图像进行解剖定位。
在7T场强下，采用定制的鸟笼线圈和参考瓶装置以及32通道pTx阵列，以在同一位置进行双原子核MRI，视野（FOV）为。对参考瓶和体模中的弛豫效应进行校正，测量图谱，并在后期处理中模拟图谱以校正采集到的数据。在体模中对这些校正进行评估，然后应用于三名健康志愿者体内。
在体模中，证明了质子和定量钠MR图像共享相同的大视野。体模测量结果显示，经过校正后钠浓度的准确性有所提高。在三名健康志愿者体内展示了大视野和定量体内MRI。
这项工作表明了在7T场强下，在自由呼吸状态下，在大视野中同时进行和定量成像的可行性，为一次性准确评估多个器官的组织钠浓度奠定了基础。
