Charlton B, Cooper S G, Brown A S, Berdoukas V A, Gurtunca N, Rudkowski R, Antony G
Biomed Pharmacother. 1985;39(1):19-22.
An insulin dependent diabetic patient was resistant to all but central venous insulin administration. For this reason plasma exchange was tried and it restored insulin responsiveness. An anti-insulin IgG antibody was identified in the patient's plasma. Plasma exchange reduced antibody levels and these correlated with daily insulin requirements. Kinetic analysis of anti-insulin antibodies, however caused us to doubt that they were the sole cause of the problem. Although the mechanism remains unclear, plasmapheresis proved to be an effective method of treating this patient's insulin resistance.
一名胰岛素依赖型糖尿病患者除了中心静脉注射胰岛素外，对其他方式均有抵抗。因此尝试了血浆置换，结果恢复了胰岛素反应性。在患者血浆中鉴定出一种抗胰岛素IgG抗体。血浆置换降低了抗体水平，且这些水平与每日胰岛素需求量相关。然而，抗胰岛素抗体的动力学分析使我们怀疑它们并非问题的唯一原因。尽管机制尚不清楚，但血浆置换被证明是治疗该患者胰岛素抵抗的有效方法。
