链脲佐菌素诱导的糖尿病对肝脏己糖转运的影响。

The effect of streptozotocin-induced diabetes on hepatic hexose transport.

作者信息

Europe-Finner G N

出版信息

Biosci Rep. 1985 May;5(5):377-82. doi: 10.1007/BF01116554.

Abstract

3-O-methyl-D-glucose (which is not metabolized in isolated parenchymal cells) was used to characterize the hexose transport process in hepatocytes prepared from 24 h fasted rats. The Vmax and Km obtained were 161 +/- 12 nmol/mg dry wt./min and 39 +/- 4 mM respectively (Europe-Finner GN, 1984, Biosci. Rep. 4, 483-489). Streptozotocin-induced diabetes decreased the Km of the system by 50% to a value of 19 +/- 6 mM without causing any change in the Vmax. Short term insulin treatment of cells prepared from 24 h diabetic rats appeared to partially return the system to normal.

摘要

3 - O - 甲基 - D - 葡萄糖（在分离的实质细胞中不被代谢）被用于表征从禁食24小时的大鼠制备的肝细胞中的己糖转运过程。得到的Vmax和Km分别为161±12 nmol/mg干重/分钟和39±4 mM（Europe - Finner GN，1984，Biosci. Rep. 4，483 - 489）。链脲佐菌素诱导的糖尿病使该系统的Km降低50%至19±6 mM的值，而Vmax没有任何变化。对从24小时糖尿病大鼠制备的细胞进行短期胰岛素治疗似乎使该系统部分恢复正常。