Department of Health Sciences, University of Milan, 20142 Milan, Italy.
Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.
Prostaglandins Leukot Essent Fatty Acids. 2024 Mar;202:102627. doi: 10.1016/j.plefa.2024.102627. Epub 2024 Jul 1.
The growing interest in Omega-3 fatty acids as diagnostic markers or new therapeutic approaches also for COVID-19 disease, led us to investigate the presence of potential correlations between Omega-3 fatty acids' levels in whole blood and days of hospitalization or admission to the paediatric intensive care unit (PICU) in 51 children with MIS-C diagnosis following SARS-CoV-2 infection. A statistically significant negative correlation was observed between days of hospitalization and docosapentaenoic acid (22:5n-3,DPA), docosahexaenoic acid (DHA) and total Omega-3 FA levels. Dividing the study group into quartiles according to Omega-3-Index (O3I), no statistically significant difference was observed with respect to the PICU admission rate. In contrast, the number of days of hospitalization in Q4 (O3I ≥ 2.51 %) was different from the number observed in groups Q1-3 (O3I < 2.51 %), with subjects showing higher O3I needing shorter hospitalizations than the subjects with lower O3I. According to previous study investigating O3I in adults affected by Sars-cov-2 we explored the levels of this nutrients in children with MIS-C. Our exploratory study shows that high DPA, DHA and O3I levels could be effective in reducing the length of hospitalization.
人们对 Omega-3 脂肪酸作为 COVID-19 疾病的诊断标志物或新的治疗方法越来越感兴趣，这促使我们研究了全血中 Omega-3 脂肪酸水平与 51 例感染 SARS-CoV-2 后出现 MIS-C 诊断的儿童住院天数或入住儿科重症监护病房（PICU）之间是否存在潜在相关性。研究观察到，住院天数与二十二碳五烯酸（22:5n-3，DPA）、二十二碳六烯酸（DHA）和总 Omega-3 FA 水平呈显著负相关。根据 Omega-3 指数（O3I）将研究组分为四组，PICU 入院率没有统计学差异。相比之下，O3I≥2.51%的第 4 组（Q4）的住院天数与 O3I<2.51%的第 1-3 组（Q1-3）不同，O3I 较高的患者比 O3I 较低的患者需要的住院时间更短。根据先前研究成人感染 SARS-CoV-2 后 O3I 的调查，我们研究了 MIS-C 患儿的这种营养素水平。我们的探索性研究表明，高 DPA、DHA 和 O3I 水平可能有效缩短住院时间。
