Barnstable C J, Hofstein R, Akagawa K
Brain Res. 1985 Jun;352(2):286-90. doi: 10.1016/0165-3806(85)90116-6.
A monoclonal antibody, HPC-1, labels only amacrine and displaced amacrine cells in adult rat retina. Reactivity with displaced amacrine cells was demonstrated by double-label immunofluorescence with HPC-1 and ganglion cell-specific reagents. HPC-1 antibody reacts with a polypeptide of apparent molecular weight 35,000. HPC-1 antibody labels migrating amacrine cells in late embryonic retinas. The results define cell-specific gene expression in relation to migration of one subclass of CNS neurons.
一种单克隆抗体HPC-1仅标记成年大鼠视网膜中的无长突细胞和移位无长突细胞。通过HPC-1与神经节细胞特异性试剂的双重标记免疫荧光法证实了其与移位无长突细胞的反应性。HPC-1抗体与表观分子量为35,000的一种多肽发生反应。HPC-1抗体标记胚胎后期视网膜中正在迁移的无长突细胞。这些结果确定了与中枢神经系统神经元一个亚类迁移相关的细胞特异性基因表达。
