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通过将二硫化钼嵌入卡拉胶水凝胶中实现的双重光疗策略来提高牙齿美白效果,用于口腔保健。

Advancing teeth whitening efficacy via dual-phototherapeutic strategy incorporating molybdenum disulfide embedded in carrageenan hydrogel for dental healthcare.

机构信息

Graduate Institute of Biomedical Materials and Tissue Engineering, International Ph.D. Program in Biomedical Engineering, Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.

Department of Urology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Taipei Medical University Research Centre of Urology and Kidney, Taipei Medical University, Taipei, Taiwan.

出版信息

Int J Biol Macromol. 2024 Sep;276(Pt 1):133647. doi: 10.1016/j.ijbiomac.2024.133647. Epub 2024 Jul 2.

Abstract

Teeth discoloration poses a widespread challenge in dental health across various regions. Conventional teeth whitening methods often result in enamel deterioration and soft tissue harm due to the utilization of incompatible whitening agents and continuous intense light exposure. Here, we propose an effective phototherapy technique for teeth whitening, employing pathways of energy transition through intersystem crossing. The integration of MoS nanosheets into carrageenan gel (MoS NSs@Carr) facilitates both photothermal-hyperthermia and the generation of reactive oxygen species (ROS) through photocatalytic processes. The efficacy of ROS generation by the phototherapeutic MoS NSs@Carr on teeth whitening in the scenario. This approach ensures comprehensive teeth whitening by eliminating deep-seated stains on the teeth while preserving structural integrity and avoiding any tissue toxicity. This research highlights the efficacy of the phototherapeutic MoS NSs@Carr for dental whitening and underscores the potential of exploring nanostructures based on MoS NSs for managing dental healthcare issue.

摘要

牙齿变色是各个地区口腔健康面临的普遍挑战。传统的牙齿美白方法由于使用不兼容的美白剂和持续强烈的光暴露,常常导致牙釉质恶化和软组织损伤。在这里,我们提出了一种有效的牙齿美白光疗技术,通过能态间跃迁途径实现能量转换。将 MoS 纳米片整合到卡拉胶凝胶中(MoS NSs@Carr),通过光催化过程促进光热-高热和活性氧物质(ROS)的产生。在模拟场景中,光疗用 MoS NSs@Carr 对牙齿美白中 ROS 生成的功效。这种方法通过消除牙齿深层污渍,同时保持结构完整性并避免任何组织毒性,实现了全面的牙齿美白。本研究强调了光疗用 MoS NSs@Carr 用于牙齿美白的功效,并突出了探索基于 MoS NSs 的纳米结构来管理口腔健康问题的潜力。

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