Han Ruiming, Zhu Dongdong, Sha Jichao, Zhao Boning, Jin Peng, Meng Cuida
Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
Jilin Provincial Key Laboratory of Precise Diagnosis and Treatment of Upper Airway Allergic Diseases, Changchun, China.
Cell Biosci. 2024 Jul 4;14(1):89. doi: 10.1186/s13578-024-01270-0.
Allergic diseases, characterized by a broad spectrum of clinical manifestations and symptoms, encompass a significant category of IgE-mediated atopic disorders, including asthma, allergic rhinitis, atopic dermatitis, and food allergies. These complex conditions arise from the intricate interplay between genetic and environmental factors and are known to contribute to socioeconomic burdens globally. Recent advancements in the study of allergic diseases have illuminated the crucial role of DNA methylation (DNAm) in their pathogenesis. This review explores the factors influencing DNAm in allergic diseases and delves into their mechanisms, offering valuable perspectives for clinicians. Understanding these epigenetic modifications aims to lay the groundwork for improved early prevention strategies. Moreover, our analysis of DNAm mechanisms in these conditions seeks to enhance diagnostic and therapeutic approaches, paving the way for more effective management of allergic diseases in the future.
过敏性疾病临床表现和症状多种多样，涵盖了一大类由免疫球蛋白E（IgE）介导的特应性疾病，包括哮喘、过敏性鼻炎、特应性皮炎和食物过敏。这些复杂病症源于遗传和环境因素之间的复杂相互作用，并且在全球范围内导致社会经济负担。过敏性疾病研究的最新进展揭示了DNA甲基化（DNAm）在其发病机制中的关键作用。本综述探讨了影响过敏性疾病中DNAm的因素，并深入研究其机制，为临床医生提供有价值的观点。了解这些表观遗传修饰旨在为改进早期预防策略奠定基础。此外，我们对这些病症中DNAm机制的分析旨在加强诊断和治疗方法，为未来更有效地管理过敏性疾病铺平道路。
