特应性的遗传学和表观遗传学基础的最新进展。
Recent progress in the genetic and epigenetic underpinnings of atopy.
机构信息
The Immune Tolerance Network, Benaroya Research Institute at Virginia Mason, Seattle, Wash; Department of Medicine, Harvard Medical School, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Mass.
Department of Medicine, School of Medicine, Johns Hopkins University, Division of Allergy and Clinical Immunology, Baltimore, Md.
出版信息
J Allergy Clin Immunol. 2023 Jan;151(1):60-69. doi: 10.1016/j.jaci.2022.10.027.
In the past 2 years, there continue to be advances in our understanding of the genetic and epigenetic underpinnings of atopy pertaining to disease risk and disease severity. The joint role of genetics and the environment has been emphasized in multiple studies. Combining genetics with family history, biomarkers, and comorbidities is further refining our ability to predict the development of individual atopic diseases as well as the advancement of the atopic march. Polygenic risk scores will be an important next step for the field moving toward clinical translation of the genetic findings thus far. A systems biology approach, as illustrated by studies of the microbiome and epigenome, will be necessary to fully understand disease development and to develop increasingly targeted therapeutics.
在过去的 2 年中，我们对特应性相关疾病风险和严重程度的遗传和表观遗传基础的理解不断取得进展。在多项研究中都强调了遗传和环境的共同作用。将遗传学与家族史、生物标志物和合并症相结合，进一步提高了我们预测个体特应性疾病发展以及特应性进程的能力。多基因风险评分将是该领域向迄今遗传发现的临床转化迈出的重要下一步。正如微生物组和表观基因组研究所示，系统生物学方法对于充分了解疾病的发展和开发越来越有针对性的治疗方法是必要的。
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