Ma Jinfeng, Wei Yujia, Sun Jingfeng, Tan Fang, Liu Penghe, Qin Guangqiu
Department of Preventive Medicine, Guangxi University of Chinese Medicine, Nanning, China.
Front Pharmacol. 2024 Jun 20;15:1385550. doi: 10.3389/fphar.2024.1385550. eCollection 2024.
although known as "Sweet Tea" (ST), has been traditionally accepted as a daily beverage and used as a folk medicine in southern China with little understanding of its potential toxicity. This study evaluated the safety of a water extract of ST by a subchronic toxicity study in Sprague-Dawley rats. A total of 80 rats were randomized divided into 4 groups with 10 males and 10 females in each group, treated with 2000, 1,000, 500 and 0 mg/kg body weight of ST extract by gavage for 90 days, respectively. The results of the study showed that ST extract did not induce treatment-related changes in the body and organ weight, food intake, blood hematology and serum biochemistry, urine indices, and histopathology in rats. The NOAEL of ST extract was observed to be 2000 mg/kg/day for rats of both sexes. These results indicated that ST extract was of low toxicity in the experimental conditions of the current study and had the potential for application in food-related products.
尽管被称为“甜茶”（ST），传统上它在中国南方被视为日常饮品并用作民间药物，但其潜在毒性却鲜为人知。本研究通过对斯普拉格-道利大鼠进行亚慢性毒性研究，评估了甜茶水提取物的安全性。总共80只大鼠被随机分为4组，每组10只雄性和10只雌性，分别以2000、1000、500和0毫克/千克体重的甜茶提取物经口灌胃90天。研究结果表明，甜茶提取物未引起大鼠体重、器官重量、食物摄入量、血液学、血清生化、尿液指标及组织病理学方面与治疗相关的变化。观察到甜茶提取物对雌雄大鼠的无观察到有害作用水平（NOAEL）均为2000毫克/千克/天。这些结果表明，在本研究的实验条件下，甜茶提取物毒性较低，具有应用于食品相关产品的潜力。
