Lemay A, Labrie F, Belanger A, Raynaud J P
Fertil Steril. 1979 Dec;32(6):646-51. doi: 10.1016/s0015-0282(16)44412-2.
Intranasal administration of two doses of potent agonist of luteinizing hormone (LH)-releasing hormone (LHRH), [D-Ser(TBU)6,des-Gly-NH2(10)]LHRH ethylamide (500 micrograms), a 8 A.M. and 5 P.M. on 1 day between day 4 and 9 following the LH peak in six normal women during two consecutive menstrual cycles shortened the luteal phase from 13.6 +/- 0.3 days to 10.9 +/- 0.3 days (mean shortening, 2.7 days; range, 0.5 to 4.5 days) and reduced plasma progesterone levels to 61.3% +/- 9.2% of control. Hormone changes were followed by daily measurements of plasma LH, follicle-stimulating hormone, 17 beta-estradiol, and progesterone during two pretreatment cycles, two treatment cycles, and two post-treatment cycles. No side effect was observed, and apparently normal cycles occurred immediately after treatment. The present data indicate that the intranasal administration of a potent LHRH agonistic analog can induce luteolysis and control time of occurrence of menses in normal women. This finding opens the possibility of a new and physiologic approach to fertility control.
在六个正常女性连续两个月经周期中，于促黄体生成素（LH）峰值出现后的第4至9天之间的某一天上午8点和下午5点，经鼻给予两剂促黄体生成素释放激素（LHRH）的强效激动剂[D - 丝氨酸（叔丁基）6，去甘氨酸 - 氨基（10）]LHRH乙酰胺（500微克），使黄体期从13.6±0.3天缩短至10.9±0.3天（平均缩短2.7天；范围为0.5至4.5天），并使血浆孕酮水平降至对照值的61.3%±9.2%。在两个预处理周期、两个治疗周期和两个治疗后周期中，通过每日测量血浆LH、促卵泡生成素、17β - 雌二醇和孕酮来跟踪激素变化。未观察到副作用，且治疗后立即出现明显正常的周期。目前的数据表明，经鼻给予强效LHRH激动剂类似物可诱导黄体溶解并控制正常女性月经发生的时间。这一发现为生育控制开辟了一种新的生理性方法的可能性。
