Lemay A, Labrie F, Ferland L, Raynaud J P
Fertil Steril. 1979 Jan;31(1):29-34. doi: 10.1016/s0015-0282(16)43755-6.
The administration of five subcutaneous 250-microgram doses of lutienizing hormone (LH)-releasing hormone (LHRH) at 4-hour intervals, the first injection being given at 8 A.M. on 1 or 2 consecutive days between days 1 and 9 following the LH surge in normal women, shortened the luteal phase from 1 to 4 days in 16 of 17 treatment cycles. There was a better efficiency of treatment when LHRH was administered on days 6 to 9 after the LH surge as compared with days 1 to 5. In fact, the luteal phase was shortened from 3.3 +/- 0.2 days versus 1.4 +/- 0.2 days (P less than 0.01) and the serum progesterone level was decreased to 44% +/- 6% versus 71% +/- 6% of control levels (P less than 0.01) when the neurohormone was injected late as compared with early in the luteal phase. The present data raise the possibility of a luteolytic effect of LHRH in normal women and indicate the interest of such a near-physiologic approach for the control of luteal function and time of appearance of menses.
在正常女性促黄体生成素（LH）高峰后的第1至9天之间，连续1或2天于上午8点开始，每隔4小时皮下注射5次250微克促黄体生成素释放激素（LHRH），在17个治疗周期中的16个周期里，黄体期从1天缩短至4天。与在LH高峰后的第1至5天给予LHRH相比，在LH高峰后的第6至9天给予LHRH时治疗效果更佳。实际上，当在黄体期后期注射神经激素时，黄体期从3.3±0.2天缩短至1.4±0.2天（P<0.01），血清孕酮水平降至对照水平的44%±6%，而早期注射时为71%±6%（P<0.01）。目前的数据增加了LHRH对正常女性黄体溶解作用的可能性，并表明这种接近生理的方法对于控制黄体功能和月经出现时间具有重要意义。
