Kessler Foundation, 1199 Pleasant Valley Way, West Orange, NJ, 07052, USA.
Department of Physical Medicine and Rehabilitation, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
J Neurol. 2024 Sep;271(9):6388-6392. doi: 10.1007/s00415-024-12524-9. Epub 2024 Jul 5.
Fatigue is a common and debilitating symptom in multiple sclerosis (MS). However, after over 100 years of inquiry its definition, measurement and understanding remains elusive. This paper describes the challenges clinicians and researchers face when assessing and treating MS patients, as well as our understanding of neural mechanisms involved in fatigue. Challenges for the future are discussed.
疲劳是多发性硬化症(MS)中常见且使人虚弱的症状。然而,经过 100 多年的探究,其定义、测量和理解仍然难以捉摸。本文描述了临床医生和研究人员在评估和治疗 MS 患者时面临的挑战,以及我们对疲劳相关神经机制的理解。还讨论了未来的挑战。