Taylor A, Townsley M I, Korthuis R J
Exp Lung Res. 1985;8(2-3):97-123. doi: 10.3109/01902148509057516.
In summary, it has been difficult to assess the permeability properties of the pulmonary capillary membrane. However, new mathematical and experimental techniques have recently been developed which are of sufficient sensitivity and specificity to begin to evaluate the complex mechanisms responsible for many forms of lung pathology. While future work will undoubtedly need to address problems associated with heterogeneity of pulmonary blood flow, and with an equally heterogeneous population of vascular permeability and fluid formation sites, we currently need to focus on using the correct experimental approaches for assessing vascular permeability. The appropriate techniques are described in the text and indicate that the measurements of reflection coefficients using lymph obtained at high vascular pressures, filtration coefficients obtained from both isolated and intact lungs, and two-pore models are useful in assessing vascular permeability.
总之，评估肺毛细血管膜的通透性特性一直很困难。然而，最近已经开发出了新的数学和实验技术，这些技术具有足够的敏感性和特异性，能够开始评估导致多种肺部病理形式的复杂机制。虽然未来的工作无疑需要解决与肺血流异质性以及同样异质的血管通透性和液体形成部位群体相关的问题，但我们目前需要专注于使用正确的实验方法来评估血管通透性。文中描述了合适的技术，这些技术表明，在高血管压力下使用淋巴液测量反射系数、从离体和完整肺组织获得过滤系数以及双孔模型，对于评估血管通透性是有用的。
