Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Surv Ophthalmol. 2024 Nov-Dec;69(6):924-936. doi: 10.1016/j.survophthal.2024.06.007. Epub 2024 Jul 3.
Retinal vein occlusion (RVO) and cerebrovascular disease share common risk factors and may be independently associated; however, the strength and nature of this association remain unclear. We conducted a systematic review and meta-analysis, informed by studies from PubMed, Scopus, EMBASE, Web of Science, and Google Scholar until January 6, 2024, aimed to clarify this relationship. Eligible studies included cohorts observing stroke incidence in RVO patients for over a year. Pooled effect estimates were calculated using random-effects models, with subgroup analyses evaluating associations between RVO types (central and branch) and stroke subtypes (ischemic and hemorrhagic). Ten cohort studies with a total of 428,650 participants (86,299 RVO patients) were included. Compared to controls, RVO patients exhibited a significantly increased risk of stroke (pooled risk ratio [RR]=1.38, 95 % confidence interval (95 %CI)=1.34-1.41). Subgroup analyses indicated elevated risk for both ischemic (RR=1.37, 95 %CI=1.32-1.42) and hemorrhagic (RR=1.55, 95 %CI=1.08-2.22) strokes in RVO patients. Additionally, both central (RR=1.50, 95 %CI=1.27-1.78) and branch (RR=1.41, 95 %CI=1.32-1.50) RVO were associated with stroke risk. Sensitivity analyses confirmed consistent results across various criteria, and funnel plots indicated no publication bias. RVO significantly increases the risk of both ischemic and hemorrhagic stroke, regardless of RVO type, suggesting a strong independent association between these conditions.
视网膜静脉阻塞 (RVO) 和脑血管疾病有共同的危险因素，可能独立相关；然而，这种关联的强度和性质仍不清楚。我们进行了一项系统评价和荟萃分析，该分析基于 PubMed、Scopus、EMBASE、Web of Science 和 Google Scholar 上的研究，截至 2024 年 1 月 6 日，旨在阐明这种关系。合格的研究包括观察 RVO 患者中风发病率超过一年的队列研究。使用随机效应模型计算汇总效应估计值，并进行亚组分析，评估 RVO 类型（中央型和分支型）和中风亚型（缺血性和出血性）之间的关联。共纳入了 10 项队列研究，总计 428650 名参与者（86299 名 RVO 患者）。与对照组相比，RVO 患者发生中风的风险显著增加（汇总风险比 [RR]=1.38，95%置信区间 [95%CI]=1.34-1.41）。亚组分析表明，RVO 患者缺血性（RR=1.37，95%CI=1.32-1.42）和出血性（RR=1.55，95%CI=1.08-2.22）中风的风险均升高。此外，中央型（RR=1.50，95%CI=1.27-1.78）和分支型（RR=1.41，95%CI=1.32-1.50）RVO 均与中风风险相关。敏感性分析证实了各种标准下的一致结果，漏斗图表明没有发表偏倚。RVO 显著增加了缺血性和出血性中风的风险，无论 RVO 类型如何，这表明这两种疾病之间存在强烈的独立关联。
