Zhu Wei, Wu Yan, Xu Ming, Wang Jin-Yu, Meng Yi-Fang, Gu Zheng, Lu Jiong
Department of Ophthalmology, Changshu NO.2 People's Hospital, Changshu, China.
Department of Ophthalmology, The First People's Hospital of Kunshan Affiliated with Jiangsu University, Suzhou, China.
PLoS One. 2015 Apr 28;10(4):e0122814. doi: 10.1371/journal.pone.0122814. eCollection 2014.
Retinal vein occlusion (RVO) is a common retinal vascular disease and it is one of the most frequently reported causes of visual damage and blindness in the elderly. The current study investigated the potential association between antiphospholipid antibodies (APLA) and RVO risk by conducting a meta-analysis of case-control studies.
A systematic literature search of Pubmed and Embase databases was conducted in August 1st, 2014. Odds ratios (ORs) were used to evaluate the associations between APLA and the incidence of RVO. A random-effects model was obtained for the quantitative synthesis.
A total of 11 studies were included in this meta-analysis. A meta-analysis of all studies assessing the risk of RVO revealed that APLA was associated with a statistically increased risk of RVO incidence (OR = 5.18, 95% CI = [3.37, 7.95]). The association between anticardiolipin antibodies (ACA) and the risk of RVO was significant (n =8, OR = 4.59, 95% CI = [2.75, 7.66]). However, the association between lupus anticoagulants (LA) and risk of RVO was non-significant (n = 5, OR = 3.90, 95% CI = [0.99, 15.37]). No significant publication bias was found in the 11 selected studies.
APLA was significantly associated with the risk of RVO. Advanced analyses showed that ACA rather than LA affected the risk of RVO. Additional well-designed and well-conducted epidemiological studies are required to further our understanding of the relationship between APLA and RVO risk.
视网膜静脉阻塞（RVO）是一种常见的视网膜血管疾病，是老年人视力损害和失明的最常见原因之一。本研究通过对病例对照研究进行荟萃分析，探讨抗磷脂抗体（APLA）与RVO风险之间的潜在关联。
2014年8月1日对Pubmed和Embase数据库进行了系统的文献检索。比值比（OR）用于评估APLA与RVO发病率之间的关联。采用随机效应模型进行定量合成。
本荟萃分析共纳入11项研究。对所有评估RVO风险的研究进行的荟萃分析显示，APLA与RVO发病率的统计学风险增加相关（OR = 5.18，95%CI = [3.37, 7.95]）。抗心磷脂抗体（ACA）与RVO风险之间的关联显著（n = 8，OR = 4.59，95%CI = [2.75, 7.66]）。然而，狼疮抗凝物（LA）与RVO风险之间的关联不显著（n = 5，OR = 3.90，95%CI = [0.99, 15.37]）。在11项入选研究中未发现显著的发表偏倚。
APLA与RVO风险显著相关。进一步分析表明，影响RVO风险的是ACA而非LA。需要更多设计良好且实施得当的流行病学研究，以加深我们对APLA与RVO风险之间关系的理解。
