Faculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam.
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan.
Cell Commun Signal. 2024 Jul 5;22(1):353. doi: 10.1186/s12964-024-01726-3.
Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death. The recent discovery of cuproptosis, a copper-dependent regulated cell death pathway that is distinct from other known regulated cell death forms, has raised interest to researchers in the field of cancer therapy. Herein, the present work aims to outline the current understanding of cuproptosis, with an emphasis on its anticancer activities through the interplay with copper-induced oxidative stress, thereby providing new ideas for therapeutic approaches targeting modes of cell death in the future.
铜是一种至关重要的微量元素，在人体的各种病理生理过程中发挥作用。铜还作为一种参与氧化还原反应的过渡金属，有助于活性氧物种（ROS）的产生。在 ROS 水平持续升高的情况下，会发生氧化应激，这与不同类型的调节性细胞死亡有关。最近发现了铜死亡，这是一种依赖铜的调节性细胞死亡途径，与其他已知的调节性细胞死亡形式不同，这引起了癌症治疗领域研究人员的兴趣。本文旨在概述铜死亡的当前认识，重点介绍其通过与铜诱导的氧化应激相互作用的抗癌活性，从而为未来针对细胞死亡模式的治疗方法提供新的思路。
