National Center for Biotechnology, Astana, 010000, Kazakhstan.
Research Centre for Medical Genetics, Moscow, 115522, Russia.
BMC Res Notes. 2024 Jul 5;17(1):187. doi: 10.1186/s13104-024-06856-y.
This study assesses the accuracy of the IrisPlex system, a genetic eye color prediction tool for forensic analysis, in the Kazakh population. The study compares previously published genotypes of 515 Kazakh individuals from varied geographical and ethnohistorical contexts with phenotypic data on their eye color, introduced for the first time in this research.
The IrisPlex panel's effectiveness in predicting eye color in the Kazakh population was validated. It exhibited slightly lower accuracy than in Western European populations but was higher than in Siberian populations. The sensitivity was notably high for brown-eyed individuals (0.99), but further research is needed for blue and intermediate eye colors. This study establishes IrisPlex as a useful predictive tool in the Kazakh population and provides a basis for future investigations into the genetic basis of phenotypic variations in this diverse population.
本研究评估了 IrisPlex 系统在哈萨克人群中的准确性，该系统是一种用于法医分析的遗传眼睛颜色预测工具。本研究比较了之前发表的来自不同地理和民族历史背景的 515 名哈萨克个体的基因型，以及他们眼睛颜色的表型数据，这是本研究首次引入的。
验证了 IrisPlex 面板在哈萨克人群中预测眼睛颜色的有效性。它在哈萨克人群中的准确性略低于西欧人群，但高于西伯利亚人群。棕色眼睛个体的灵敏度显著较高（0.99），但对于蓝色和中间色眼睛还需要进一步研究。本研究确立了 IrisPlex 系统在哈萨克人群中的有用预测工具，并为未来研究该多样化人群中表型变异的遗传基础提供了基础。
