Stanhope R, Abdulwahid N A, Adams J, Jacobs H S, Brook C G
Horm Res. 1985;22(1-2):74-7. doi: 10.1159/000180075.
The induction of puberty by the administration of subcutaneous 15-micrograms pulses of gonadotrophin-releasing hormone (GnRH) every 90 min during day and night is described in two patients. Too rapid an induction of puberty occurred in one patient while initial progress in the other ceased after the development of pituitary desensitisation. We have attributed these results to the use of GnRH pulses in too high amplitude, and we suggest a more appropriate dose regimen.
两名患者接受了皮下注射促性腺激素释放激素（GnRH）的治疗，每90分钟注射15微克脉冲剂量，昼夜不停，以此诱导青春期发育。其中一名患者青春期发育过快，而另一名患者在垂体脱敏后，青春期初始发育进程停止。我们将这些结果归因于GnRH脉冲剂量过高，并提出了更合适的给药方案。
