Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Metabolic Vascular Diseases Key Laboratory of Sichuan Province, and Metabolic Vascular Diseases Key Laboratory of Sichuan-Chongqing Cooperation, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Sichuan Clinical Research Center for Nephropathy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolic Disease, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
Metabolic Vascular Diseases Key Laboratory of Sichuan Province, and Metabolic Vascular Diseases Key Laboratory of Sichuan-Chongqing Cooperation, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Sichuan Clinical Research Center for Nephropathy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Sichuan Clinical Research Center for Diabetes and Metabolic Disease, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Experimental Medicine Center, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
Biomed Pharmacother. 2024 Aug;177:117065. doi: 10.1016/j.biopha.2024.117065. Epub 2024 Jul 5.
Metabolic diseases are a group of disorders caused by metabolic abnormalities, including obesity, diabetes, non-alcoholic fatty liver disease, and more. Increasing research indicates that, beyond inherent metabolic irregularities, the onset and progression of metabolic diseases are closely linked to alterations in the gut microbiota, particularly gut bacteria. Additionally, fecal microbiota transplantation (FMT) has demonstrated effectiveness in clinically treating metabolic diseases, notably diabetes. Recent attention has also focused on the role of gut viruses in disease onset. This review first introduces the characteristics and influencing factors of gut viruses, then summarizes their potential mechanisms in disease development, highlighting their impact on gut bacteria and regulation of host immunity. We also compare FMT, fecal filtrate transplantation (FFT), washed microbiota transplantation (WMT), and fecal virome transplantation (FVT). Finally, we review the current understanding of gut viruses in metabolic diseases and the application of FVT in treating these conditions. In conclusion, FVT may provide a novel and promising treatment approach for metabolic diseases, warranting further validation through basic and clinical research.
代谢性疾病是一组由代谢异常引起的疾病，包括肥胖、糖尿病、非酒精性脂肪肝等。越来越多的研究表明，除了内在的代谢紊乱外，代谢性疾病的发生和发展与肠道微生物群的改变密切相关，特别是肠道细菌。此外，粪便微生物群移植（FMT）已被证明在临床上治疗代谢性疾病，特别是糖尿病方面有效。最近人们也关注了肠道病毒在疾病发生中的作用。本综述首先介绍了肠道病毒的特征和影响因素，然后总结了它们在疾病发展中的潜在机制，强调了它们对肠道细菌和宿主免疫调节的影响。我们还比较了粪便微生物群移植（FMT）、粪便滤液移植（FFT）、洗涤微生物群移植（WMT）和粪便病毒组移植（FVT）。最后，我们综述了肠道病毒在代谢性疾病中的作用以及 FVT 在治疗这些疾病中的应用。总之，FVT 可能为代谢性疾病提供一种新颖而有前途的治疗方法，值得通过基础和临床研究进一步验证。
