Centre des Sciences Du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, 21000, Dijon, France.
CRM2 (UMR UL-CNRS 7036), Faculté des Sciences et Technologies, Université de Lorraine, BP 70239, 54506, Vandoeuvre-lès-Nancy Cedex, France.
Phytochemistry. 2024 Oct;226:114204. doi: 10.1016/j.phytochem.2024.114204. Epub 2024 Jul 4.
From the root barks of a Central African tree Millettia dubia De Wild. (Fabaceae), ten previously undescribed oleanane-type glycosides were isolated by various chromatographic protocols. Their structures were elucidated by spectroscopic methods, mainly 2D NMR experiments and mass spectrometry, as mono- and bidesmosidic glycosides of mesembryanthemoidigenic acid, hederagenin and oleanolic acid. The stimulation of the sweet taste receptor TAS1R2/TAS1R3 by these glycosides was evaluated, and structure/activity relationships were proposed. Two of them showed an agonist effect on TAS1R2/TAS1R3.
从中非树木 Millettia dubia De Wild 的根皮中（豆科），通过各种色谱方案分离出了十种以前未描述过的齐墩果烷型糖苷。通过光谱方法，主要是二维 NMR 实验和质谱法，将它们的结构阐明为半边旗二酸、山茱萸苷元和齐墩果酸的单和双糖苷。评估了这些糖苷对甜味受体 TAS1R2/TAS1R3 的刺激作用，并提出了结构/活性关系。其中两种对 TAS1R2/TAS1R3 具有激动作用。
