Obana Y, Nishino T, Tanino T
J Antibiot (Tokyo). 1985 Jul;38(7):941-7. doi: 10.7164/antibiotics.38.941.
The therapeutic efficacy of six beta-lactam and aminoglycoside antibiotics were compared in diabetic mice with experimentally induced Klebsiella pneumoniae pneumonia. beta-Lactams caused a reduction in the numbers of bacteria, with clearance of bacteria from the lungs of diabetic and normal mice. The effect in diabetic mice, however, was very poor. In contrast thereto, no remarkable difference was seen between diabetic and normal mice when treated with aminoglycosides. The concentration of the test antibiotics to the lungs in diabetic mice was lower than in normal mice. The aminoglycosides were more effective than the beta-lactams. These data suggest that in treating acute and more chronic forms of pulmonary infection caused by K. pneumoniae in diabetic mice aminoglycoside antibiotics are particularly valuable, whereas beta-lactams must be given in large quantities using multiple administrations.
在实验性诱导肺炎克雷伯菌肺炎的糖尿病小鼠中，比较了六种β-内酰胺类抗生素和氨基糖苷类抗生素的治疗效果。β-内酰胺类抗生素可减少细菌数量，使糖尿病小鼠和正常小鼠肺部的细菌清除。然而，其对糖尿病小鼠的效果很差。与此相反，用氨基糖苷类抗生素治疗时，糖尿病小鼠和正常小鼠之间未观察到显著差异。糖尿病小鼠肺部的受试抗生素浓度低于正常小鼠。氨基糖苷类抗生素比β-内酰胺类抗生素更有效。这些数据表明，在治疗糖尿病小鼠由肺炎克雷伯菌引起的急性和更慢性肺部感染形式时，氨基糖苷类抗生素特别有价值，而β-内酰胺类抗生素必须大量多次给药。
