School of Nursing, Jilin University, Changchun, Jilin Province, China.
The First Hospital of Jilin University, Changchun, Jilin province, China.
Semin Oncol Nurs. 2024 Oct;40(5):151690. doi: 10.1016/j.soncn.2024.151690. Epub 2024 Jul 8.
It is not clear how chemotherapy-related cognitive impairment and self-care ability affect the quality of life of women with breast cancer. The purpose of this study was to explore the relationships between chemotherapy-related cognitive impairment, self-care ability, and quality of life in breast cancer patients, and test whether self-care ability plays a mediating role in the association between cognitive impairment and quality of life.
This study was a cross-sectional study, conducted in China in 2022. Self-reported scales were used to assess cognitive function, self-care ability, and quality of life. Data were analyzed using descriptive statistics, spearman correlation analysis and hierarchical multiple regression analyses, the SPSS Process program was used to explore the mediating effect of self-care ability.
A total of 218 participants were investigated, and approximately 79.3% of patients experienced mild chemotherapy-related cognitive impairment, the mean quality of life score was 59.96 ± 14.15, and the mean self-care ability score was 107.4 ± 24.09. Significant correlations among cognitive impairment, self-care ability, and quality of life were observed (P < .05). Additionally, self-care ability played a partial mediating role between cognitive impairment and quality of life (P < .05), accounting for 24.3% and 22.3%, respectively.
Chemotherapy-related cognitive impairment and self-care ability are factors affecting the quality of life of breast cancer survivors. Self-care ability mediates the relationship between cognitive impairment and quality of life. Enhancing patients' self-care ability can improve the quality of life of patients with cognitive impairment.
In the future, oncology nurses should not only pay attention to the severity of cognitive impairment, but also assess the level of patients' self-care ability, provide relevant medical and healthcare guidance, train self-management behavior and strengthen self-care ability by integrating multidisciplinary forces to improve the quality of life of breast cancer patients effectively.
化疗相关认知障碍和自我护理能力如何影响乳腺癌患者的生活质量尚不清楚。本研究旨在探讨乳腺癌患者化疗相关认知障碍、自我护理能力与生活质量之间的关系，并检验自我护理能力是否在认知障碍与生活质量之间起中介作用。
这是一项在中国 2022 年进行的横断面研究。采用自我报告量表评估认知功能、自我护理能力和生活质量。采用描述性统计、Spearman 相关分析和分层多元回归分析进行数据分析，采用 SPSS Process 程序探索自我护理能力的中介作用。
共调查了 218 名参与者，约 79.3%的患者出现轻度化疗相关认知障碍，生活质量平均得分为 59.96±14.15，自我护理能力平均得分为 107.4±24.09。认知障碍、自我护理能力和生活质量之间存在显著相关性（P<.05）。此外，自我护理能力在认知障碍和生活质量之间起部分中介作用（P<.05），分别占 24.3%和 22.3%。
化疗相关认知障碍和自我护理能力是影响乳腺癌幸存者生活质量的因素。自我护理能力中介了认知障碍与生活质量之间的关系。提高患者的自我护理能力可以改善认知障碍患者的生活质量。
今后，肿瘤护士不仅要关注认知障碍的严重程度，还要评估患者自我护理能力的水平，通过整合多学科力量，提供相关医疗保健指导，培训自我管理行为，加强自我护理能力，有效提高乳腺癌患者的生活质量。
