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化疗后、非化疗乳腺癌幸存者和非癌症患者的认知感知。

Cognitive Perception among Post-Chemotherapy, Non-Chemotherapy Breast Cancer Survivors and Non-Cancer.

机构信息

Department of Medical Surgical Nursing, Faculty of Nursing, Universitas Syiah Kuala, Banda Aceh, Indonesia.

Medical Surgical Nursing Department, Faculty of Nursing, Universitas Indonesia, Depok, East Java, Indonesia.

出版信息

Asian Pac J Cancer Prev. 2021 Jun 1;22(6):1775-1780. doi: 10.31557/APJCP.2021.22.6.1775.

Abstract

OBJECTIVE

This study aims to compare the cognitive function perceived by post-chemotherapy breast cancer survivors, breast cancer survivors without chemotherapy, and non-cancer woman patients.

METHODS

This study was conducted by a descriptive comparative method. The respondents consisted of 82 survivors of post-chemotherapy breast cancer, 81 non-chemotherapy breast cancer survivors, and 80 non-cancer woman patients who were recruited using consecutive sampling. The data were collected from October until December 2017 by using a FACT-Cog version 3 questionnaire. Data analysis was performed by using a comparative test of Kruskal-Wallis followed by a Mann-Whitney posthoc analysis.

RESULTS

The results showed that the median of cognitive function perception in breast cancer survivors post-chemotherapy, non-chemotherapy, and non-cancerous women are 94 (52-122), 113 (53-130), and 121 (69-132), respectively. Mann-Whitney's post-hoc analysis showed a significantly different perception of cognitive function between post-chemotherapy survivors and non-chemotherapy survivors; also between post-chemotherapy survivors and non-cancer women, and between non-chemotherapy survivors with non-cancer women.

CONCLUSION

Perceived cognitive impairment, comments from others, perceived cognitive abilities, and effects on quality of life in breast cancer survivors who received chemotherapy are significantly different as compared to the survivor group without chemotherapy and non-cancerous healthy women.

摘要

目的

本研究旨在比较化疗后乳腺癌幸存者、未化疗乳腺癌幸存者和非癌症女性患者的认知功能感知。

方法

本研究采用描述性对比方法进行。研究对象包括 82 名化疗后乳腺癌幸存者、81 名非化疗乳腺癌幸存者和 80 名非癌症女性患者,采用连续抽样法招募。数据于 2017 年 10 月至 12 月期间使用 FACT-Cog 版本 3 问卷收集。采用 Kruskal-Wallis 比较检验和随后的 Mann-Whitney 事后分析进行数据分析。

结果

结果显示,化疗后乳腺癌幸存者、未化疗乳腺癌幸存者和非癌症女性的认知功能感知中位数分别为 94(52-122)、113(53-130)和 121(69-132)。Mann-Whitney 事后分析显示,化疗后幸存者与未化疗幸存者、化疗后幸存者与非癌症女性以及未化疗幸存者与非癌症女性之间的认知功能感知存在显著差异。

结论

与未接受化疗的幸存者组和非癌症健康女性相比,接受化疗的乳腺癌幸存者对认知障碍的感知、他人的评价、感知的认知能力以及对生活质量的影响存在显著差异。

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本文引用的文献

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From the Bottom-Up: Chemotherapy and Gut-Brain Axis Dysregulation.自下而上:化疗与肠脑轴失调
Front Behav Neurosci. 2018 May 22;12:104. doi: 10.3389/fnbeh.2018.00104. eCollection 2018.

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