Shah P M, Schneider K, Stille W
J Antimicrob Chemother. 1985 Jun;15 Suppl C:165-71. doi: 10.1093/jac/15.suppl_c.165.
Sch 34343 inhibited 50% of the 105 bacterial strains tested at concentrations ranging from less than 1.25 to 5.0 mg/l and 90% at 5.0 to 10.0 mg/l. Against Escherichia coli and Klebsiella pneumoniae strains with cefotaxime MICs greater than 5.0 mg/l, 1.0-4.0 mg/l of Sch 34343 was required for inhibition. At concentrations equal to 1 X and 8 X MIC, Sch 34343 rapidly reduced the inoculum by 99% and 99.9%. Against Staphylococcus aureus higher concentrations had a lesser bactericidal activity. Sch 34343 and gentamicin were synergistic at concentrations that were separately subinhibitory.
Sch 34343对所测试的105株细菌中的50%在浓度低于1.25至5.0毫克/升时具有抑制作用，在5.0至10.0毫克/升时对90%的细菌有抑制作用。对于头孢噻肟最低抑菌浓度大于5.0毫克/升的大肠杆菌和肺炎克雷伯菌菌株，需要1.0 - 4.0毫克/升的Sch 34343才能产生抑制作用。在等于1倍和8倍最低抑菌浓度的情况下，Sch 34343能迅速将接种量减少99%和99.9%。对于金黄色葡萄球菌，较高浓度的杀菌活性较低。Sch 34343和庆大霉素在各自低于抑制浓度时具有协同作用。
