Ramineni Aadhyasri, Faateh Muhammad, Mehdizadeh-Shrifi Amir, Hayes Don, Morales David L S
Division of Cardiothoracic Surgery, The Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
Division of Pulmonology, Cincinnati Children's Hospital Medical Center, The Heart Institute, Cincinnati, OH, USA.
Lung. 2024 Aug;202(4):459-464. doi: 10.1007/s00408-024-00718-x. Epub 2024 Jul 6.
Data on concomitant cardiac surgery (CCS) performed during pediatric lung transplantation (LTx) is limited. Therefore, we conducted a multi-institutional analysis to identify the incidence and outcomes of CCS in pediatric (< 18 years) LTx recipients by merging data (2004-2023) from the United Network for Organ Sharing (UNOS) and Pediatric Health Information System (PHIS) databases. Of the total of 596 pediatric LTx recipients, 87 (15%) underwent CCS. The majority of these cardiac surgeries were atrial septal defect (ASD) closure (90%) followed by aortic arch/descending aortic repair (3%), atrial repair (3%), ventricular septal defect closure (2%), patent ductus arteriosus ligation (2%), and tricuspid valve repair (2%). The median age at LTx was 3 years (IQR: 0-12). Pulmonary hypertension (PHT) was the predominant indication for LTx (54%). Survival to discharge was 94% and 5-years survival was 64%. Our findings indicate CCS in children undergoing LTx has acceptable outcomes.
关于小儿肺移植（LTx）期间同期进行心脏手术（CCS）的数据有限。因此，我们通过合并器官共享联合网络（UNOS）和儿科健康信息系统（PHIS）数据库（2004 - 2023年）的数据，进行了一项多机构分析，以确定小儿（<18岁）LTx受者中CCS的发生率和结局。在总共596例小儿LTx受者中，87例（15%）接受了CCS。这些心脏手术大多数是房间隔缺损（ASD）封堵术（90%），其次是主动脉弓/降主动脉修复术（3%）、心房修复术（3%）、室间隔缺损封堵术（2%）、动脉导管未闭结扎术（2%）和三尖瓣修复术（2%）。LTx时的中位年龄为3岁（四分位间距：0 - 12岁）。肺动脉高压（PHT）是LTx的主要指征（54%）。出院生存率为94%，5年生存率为64%。我们的研究结果表明，接受LTx的儿童进行CCS有可接受的结局。
