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对数字化巴氏涂片图像中的细胞进行逐像素分割。

Pixel-wise segmentation of cells in digitized Pap smear images.

机构信息

Department of Data Science and Visualization, Faculty of Informatics, University of Debrecen, Debrecen, Hungary.

Department of Pathology, Kenezy Gyula Hospital and Clinic, University of Debrecen, Debrecen, Hungary.

出版信息

Sci Data. 2024 Jul 6;11(1):733. doi: 10.1038/s41597-024-03566-9.

DOI:10.1038/s41597-024-03566-9
PMID:38971865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11227563/
Abstract

A simple and cheap way to recognize cervical cancer is using light microscopic analysis of Pap smear images. Training artificial intelligence-based systems becomes possible in this domain, e.g., to follow the European recommendation to screen negative smears to reduce false negative cases. The first step for such a process is segmenting the cells. A large and manually segmented dataset is required for this task, which can be used to train deep learning-based solutions. We describe a corresponding dataset with accurate manual segmentations for the enclosed cells. Altogether, the APACS23 (Annotated PAp smear images for Cell Segmentation 2023) dataset contains about 37 000 manually segmented cells and is separated into dedicated training and test parts, which could be used for an official benchmark of scientific investigations or a grand challenge.

摘要

一种简单而廉价的宫颈癌识别方法是利用巴氏涂片图像的光学显微镜分析。在这个领域,训练基于人工智能的系统成为可能,例如,遵循欧洲的建议对阴性涂片进行筛查,以减少假阴性病例。这个过程的第一步是对细胞进行分割。这项任务需要一个大型的、手动分割的数据集,该数据集可用于训练基于深度学习的解决方案。我们描述了一个相应的数据集,其中包含封闭细胞的准确手动分割。总的来说,APACS23(2023 年用于细胞分割的注释巴氏涂片图像)数据集包含大约 37000 个手动分割的细胞,并分为专门的训练和测试部分,可用于科学研究的官方基准测试或大型挑战赛。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/369217f3de82/41597_2024_3566_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/fa3bc2c8d32a/41597_2024_3566_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/1a2d4eb72b09/41597_2024_3566_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/09131eb88f57/41597_2024_3566_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/369217f3de82/41597_2024_3566_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/fa3bc2c8d32a/41597_2024_3566_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/1a2d4eb72b09/41597_2024_3566_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/09131eb88f57/41597_2024_3566_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74b8/11227563/369217f3de82/41597_2024_3566_Fig4_HTML.jpg

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本文引用的文献

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Comput Biol Med. 2022 Nov;150:106194. doi: 10.1016/j.compbiomed.2022.106194. Epub 2022 Oct 14.
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Comparison of the Hologic Genius Digital Diagnostics System with the ThinPrep Imaging System-A retrospective assessment.Hologic Genius 数字诊断系统与 ThinPrep 成像系统的比较——一项回顾性评估。
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Local Label Point Correction for Edge Detection of Overlapping Cervical Cells.
用于重叠宫颈细胞边缘检测的局部标记点校正
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Cancer Cytopathol. 2022 Jun;130(6):407-414. doi: 10.1002/cncy.22560. Epub 2022 Mar 15.
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Detection of Cervical Cancer Cells in Whole Slide Images Using Deformable and Global Context Aware Faster RCNN-FPN.使用可变形和全局上下文感知的 Faster RCNN-FPN 检测全幻灯片图像中的宫颈癌细胞。
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Cric searchable image database as a public platform for conventional pap smear cytology data.Cric 可搜索图像数据库作为常规巴氏涂片细胞学数据的公共平台。
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Optimization for Medical Image Segmentation: Theory and Practice When Evaluating With Dice Score or Jaccard Index.使用骰子分数或杰卡德指数评估时医学图像分割的优化:理论与实践
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