Transplant and Oncology Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Transplant Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Transpl Infect Dis. 2024 Nov;26 Suppl 1:e14334. doi: 10.1111/tid.14334. Epub 2024 Jul 7.
Human herpes virus 8 (HHV-8) or Kaposi sarcoma herpesvirus (KSHV) is an opportunistic oncovirus that causes multiple pathologic entities.
We present a case of fatal HHV-8-associated multisystem illness with disseminated Kaposi sarcoma and HHV8-associated lymphoproliferative disorder with systemic inflammation. We conducted a narrative review of the literature on HHV-8 in transplantation with a goal of illuminating the spectrum of HHV-8-associated diseases in this vulnerable population, modes of disease transmission, and the potential role for donor and recipient screening.
HHV-8-associated KS, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD), and KSHV inflammatory cytokine disorder (KICS) may affect transplant recipients; with the exception of KS, these conditions are rare but carry high morbidity and mortality.
HHV-8-associated diseases have diverse and protean manifestations in transplant recipients, with potentially fatal outcomes. HHV-8 seroprevalence among organ donors and the magnitude of risk for donor-derived HHV-8 infection or clinically significant disease remain unknown and require further study.
人类疱疹病毒 8 型（HHV-8）或卡波济肉瘤相关疱疹病毒（KSHV）是一种机会性致癌病毒，可引起多种病理实体。
我们报告了一例致命的 HHV-8 相关多系统疾病，伴有弥漫性卡波济肉瘤和 HHV8 相关淋巴增生性疾病伴全身炎症。我们对移植中的 HHV-8 进行了文献综述，旨在阐明该脆弱人群中 HHV-8 相关疾病的范围、疾病传播模式以及供体和受体筛查的潜在作用。
HHV-8 相关的卡波济肉瘤、原发性渗出性淋巴瘤（PEL）、多中心 Castleman 病（MCD）和 KSHV 炎症细胞因子紊乱（KICS）可能影响移植受者；除了卡波济肉瘤，这些疾病很少见，但发病率和死亡率很高。
HHV-8 相关疾病在移植受者中有多种表现形式，且可能导致致命后果。器官供体中 HHV-8 的血清阳性率以及供体源性 HHV-8 感染或有临床意义的疾病的风险程度尚不清楚，需要进一步研究。
